Evaluation of Antiulcer Activity of Peltophorum Pterocarpum
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 6
Abstract
Introduction: Peltophorum pterocarpum is a rich source for phenols and the wood, leaves, and flowers of the plant are used as medicinal agents in traditional medicine. Peptic ulcer is a major disease of gastrointestinal tract, affecting nearly 40 lac people each year worldwide and affects 10% of world population with different aetiologies. Peltophorum pterocarpum consists of phenols and flavonoids, tannins which have potential antioxidant and cytoprotective activity. Aim: To evaluate the antiulcer activity of methanolic extract of the leaves of Peltophorum pterocarpum (MEPP) on albino rats. Materials and Methods: The rats were divided into four groups as control, standard, test 1 (extract: 100 mg/kg) and test 2 (extract: 200 mg/kg) with six rats in each group. Gastric lesions were induced by oral administration of indomethacin (20 mg/kg) followed by pylorus ligation. Standard group of animals were treated with misoprostol and test group of animals were treated with MEPP at doses of 100 and 200 mg/kg. To determine the antiulcer activity of extract, mean ulcer index, free acidity and total acidity were evaluated. Results: Ulcer index was significantly decreased at p<0.01 in MEPP treated groups as compared to control group. Total and free acidity was significantly decreased at p<0.01 in MEPP treated groups as compared to control group. Histological analysis also supported the gastro protective effect of MEPP treated groups when compared with control groups. Conclusion: The study revealed that MEPP exhibited potential antiulcer activity and showed dose dependent antiulcer effect.
Authors and Affiliations
Bhupalam Pradeepkumar, CP Bhavyamadhuri, Y Padmanabhareddy, KV Veerabhadrappa, Gorantla Narayana, C Haranath, K Somasekharreddy, Akkiraju Sudheer
Keywords
Related Articles
- EP ID EP348431
- DOI 10.7860/JCDR/2017/26171.9998
- Views 87
- Downloads 0
Is Alexidine Really More Effective than Chlorhexidine?
Letter to Editor
Dengue Haemorrhagic Encephalitis: Rare Case Report with Review of Literature
Dengue is an endemic arboviral infection prevalent especially in tropical countries including Southern and Southeast Asia. Central Nervous System (CNS) involvement in dengue infection is uncommon. Haemorrhagic encephalit...
Role of Sonographic Gray-Scale Pattern Recognition in the Diagnosis of Adnexal Masses
Introduction: Characterization of adnexal masses as benign or malignant is of utmost importance for optimal management and prognostication. Ultrasound examination plays an important role in the differentiation of adnexal...
Molecular Strain Typing of Clinical Isolates, Trichophyton rubrum using Non Transcribed Spacer (NTS) Region as a Molecular Marker
Introduction: Dermatophytes are a group of fungi which infect keratinized tissues and causes superficial mycoses in humans and animals. The group comprises of three major genera, Trichophyton, Microsporum and Epidermophy...
Esthesioneuroblastoma Presenting with Bilateral Proptosis and Blindness in a Child: A Case Report
Esthesioneuroblastoma is a rare malignant tumour of the olfactory epithelium. The most common symptom is related to unilateral nasal obstruction. It rarely presents with bilateral proptosis and blindness. We report a 21-...