Evaluation of Antiulcerogenic Activity of Bacopa Monnieri (LINN.) on Ethanol-Induced Gastric Injury In Mice
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 6
Abstract
Bacopa monnieri (L) is a renowned medicinal plant for its numerous therapeutic activities against a number of ailments. Bangladeshi species of B. monnieri has been previously reported for its anti-inflammatory activities. Therefore, the present investigation involves phytochemical screening and evaluation of antiulcerogenic activity of B. monnieri extracts of different solvent medium by in-vivo analysis. The study was conducted by using ethanol-induced gastric injury in Swiss albino mice model to evaluate anti-ulcer effect of B. monnieri (whole plant). Three different solvent systems (water, ethanol and carbon tetrachloride) were used to prepare plant extract. Animals were pretreated with 200mg/kg and 400mg/kg (body weight, p.o.) of the plant extracts in 0.2% tween 80 where omeprazole (20 mg/kg b.w. in 0.2% tween 80, p.o.) was used as the reference drug. The extent of gastric injury was evaluated by assessment of gross appearance of gastric areas to determine ulcer index and histology of stomach. A dose-dependent therapeutic effect against gastric ulcer was found with all three extracts of Bacopa monnieri where ethanolic extract of the plant showed statistically significant result(**p< 0.01) when compared with ulcerogenic animal group. Furthermore, the therapeutic effect of 400mg/kg (b.w. p.o.) of B. monnieri ethanolic extract exhibited close relation with pretreatment by omeprazole. The present study suggests ethanol as a suitable extraction medium for Bacopa monnieri (L) in order to evaluate its antiulcerogenic activity. Treatment with this extract leads to extensive protection against gastric ulcer providing a scientific basis for its traditional uses as a cure for ulcer.
Authors and Affiliations
Rubaba Karim
Keywords
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