Evaluation of anxiolytic and hypoglycemic activity of methanolic extract of Ixora cuneifolia in an animal model
Journal Title: Journal of Coastal Life Medicine - Year 2017, Vol 5, Issue 10
Abstract
Objective: To investigate anxiolytic and hypoglycemic activity of Ixora cuneifolia (Family: Rubiaceae) in an experimental animal model. Methods: Anxiolytic test was performed by elevated plus maze (EPM) and hole-board method. Hypoglycemic activity was measured in glucose-loaded Swiss albino mice by glucose tolerance test. Results: The methanol extract of Ixora cuneifolia exhibited dose-dependent and statistically significant (P < 0.05) anxiolytic activity at doses of 200 and 400 mg/kg. Reduction of glucose level was observed with the highest dose 400 mg/kg of the extract in glucose tolerance test. Conclusions: The better anxiolytic and hypoglycemic activities in the present study could be due to the presence of different chemical constituents like alkaloids, flavonoids, saponin, phenols and tannins in this methanolic extract.
Authors and Affiliations
Keywords
Related Articles
- EP ID EP236756
- DOI 10.12980/jclm.5.2017J7-111
- Views 115
- Downloads 0
Diphyllobothriasis caused by Diphyllobothrium latum in Southeast Asia: A new emerging fish-borne disease
Diphyllobothriasis caused by Diphyllobothrium latum is an important helminthiasis. It is seen in many non-tropical countries. Since it is a marine fish-borne zoonosis, it becomes an important issue in coastal medicine. H...
Antioxidant potential of brans of twenty-nine red and white rice (Oryza sativa L.) varieties of Sri Lanka
Objective: To evaluate antioxidant properties of brans of twenty-nine red and white rice varieties of Sri Lanka. Methods: Brans of 21 new improved (NI), 2 old improved (OI) and 6 traditional red and white rice varieties...
Hepatoprotective potential of three Sargassum species from Karachi coast against carbon tetrachloride and acetaminophen intoxication
Objective: To assess the hepatoprotective effect of ethanol extracts of Sargassum variegatum (S. variegatum), Sargassum tenerrimum (S. tenerrimum) and Sargassum binderi occurring at Karachi coast against carbon tetrachlo...
Variability in patterns of macro-epiphytic leaf community of Posidonia oceanica in the Islands of Kuriate: Western coast of Tunisia
Objective: To test the response of the epiphyte community structure and biomass of the Posidonia oceanica (P. oceanica) leaves to natural disturbance. Methods: Sampling of P. oceanica was carried in winter and summer on...
Ecological and biochemical analyses of the brown alga Turbinaria ornata (Turner) J. Agardh from Red Sea coast, Egypt
Objective: To study ecological parameters and biochemical composition of brown seaweed, Turbinaria ornata (T. ornata) collected from Hurghada shores, Red Sea coast of Egypt during September, October and November, 2015. M...