Evaluation of BCG Vaccine in Excessive Dermal Reactivity Test
Journal Title: International Journal of Biomedical and Advance Research - Year 2015, Vol 6, Issue 11
Abstract
BCG vaccine has been in use globally to control the tuberculosis since the year 1921 and there has been significant achievement to curtail the disease. The important tests as per pharmacopoeial requirements including count of viable units (CVU) and excessive dermal reactivity (EDR) are required to be performed for ensuring the quality of BCG vaccine. In order to see the trend analysis of EDR of BCG vaccine used in India, a study has been carried out using 35 batches of BCG vaccine manufactured by two different manufacturers. The results of EDR of 16 batches of manufacturer-1 and 19 batches from manufacturer-2 ranged from 2.7mm to 3.2mm and1.9mm to 3.9mm respectively and the results are not markedly different from that of reference vaccine. The preliminary observation based on 16 batches suggests that there is some correlation between CVU and EDR of BCG vaccine, however more batches of BCG vaccine need to be tested to draw a clear correlation between these two tests. The critical EDR test is required to be performed regularly till the suitable alternate in vitro method is established. Overall results of the study suggest that BCG vaccine used in India is safe and potent.
Authors and Affiliations
Harit Kasana, Gunjan Sikarwar, Lavanyam Pathania, Shalini Tewari, Manjula Kiran, G. R. Soni, Neeraj Malik, Surinder Singh
Keywords
Related Articles
- EP ID EP355352
- DOI 10.7439/ijbar.v6i11.2649
- Views 115
- Downloads 0
Evaluation of cardioprotective activity of ethanolic extract of dried leaves of Cinnamomum tamala in rats
The present study was designed to scientifically evaluate the cardio protective potential of Ethanolic Extract of dried leaves of Cinnamomum tamala (Family: Lauraceae) (EECT), against doxorubicin induced myocardial infar...
Association of Deviated Nasal Septum and Sinusitis: A Radiological Study
Introduction:Deviation of nasal septum (DNS) is the most common anatomical variant in sinonasal region. It is usually asymptomatic, but it sometimes can cause different sinonasal symptoms. The severity of the symptoms is...
Is partograph being correctly filled or just giving false security
Context : Retrospective study was carried out to answer whether or not the partographs that are used to monitor mothers in labour are recorded to the standard. A fuller understanding of this process will be important to...
A prospective, randomized and double blind once-monthly oral Ibandronate and Risedronate in post-menopausal osteoporosis leprosy patients
Objectives: The aim of the current investigation was to compare relative efficacy, tolerability and adherence of once monthly regimen of oral Ibandronate and Risedronate in postmenopausal osteoporotic leprosy patients wi...
Pregnancy outcome in patients with threatened abortion and abnormal early sonographic markers: A prospective study
Objectives : The study examines the pregnancy outcome in patients with threatened abortion and patients with abnormal early sonography markers . Study Design : This was a prospective study Method: This prospective study...