Evaluation of C. cassia Effectiveness in Behavioral Modulation of Haloperidol Induced Parkinson’s Disease (Mice Model)
Journal Title: Journal of Pharmaceutical Research International - Year 2016, Vol 13, Issue 6
Abstract
Aims: This study was undertaken to evaluate the effectiveness of behavioral modulation of C. cassia extract against Haloperidol induced Parkinson’s disease (PD) in albino mice. Study Design: The study used animal models to test the effect of Haloperidol in development of PD and effectiveness of C. cassia extract in behavioral modulation in mice before & after the treatment of PD. Place and Duration of Study: Pharmacology Lab, Department of Pharmacology, Faculty of Pharmacy, Hajvery University, Lahore-Pakistan. Methodology: The study was divided into three phases; During Phase I, all subjects were randomly divided into four groups comprising of 7 subjects each through flip of coin method and were trained for wire hanging test, grip strength test, Vertical rod test, and swim test for seven days. During Phase II, PD was induced by intraperitoneally administering 1 mg / kg / day of Haloperidol for 7 days. Animals of Group A (Normal) was served as control, Group B (Diseased, HP) received haloperidol (1 mg/kg / day), Group C (HP+CN-100), and Group D (HP+CN-200) were administered C. cassia extract, 100 mg and 200 mg per kg of body weight orally for 36 days respectively. During Phase III the above mentioned test were performed and effects of C. cassia extracts were recorded. The results of the present study revealed that dose of C. cassia extract 100 mg/kg is more safe and effective than 200 mg/kg. However, in swim test Group D (HP+CIN-200) is more statistically significant as compared to Group B (Diseased, HP) with P = .003. Conclusion: The current study concludes that oral administration of C. cassia extract modulates haloperidol induced behavioral changes in mice. The present study suggests that extract will be helpful as adjunct therapy along with standard therapy of Levodopa/Carbidopa.
Authors and Affiliations
Awais Ali Zaidi, Tanveer Ahmed Khan, Lubna Shakir, Mahtab Ahmad Khan, Muhammad Yousaf, Arsalan Ali, Atif Saeed, Zaka-Ur-Rehman . , Atta-Ur-Rehman .
Keywords
Related Articles
- EP ID EP342561
- DOI 10.9734/BJPR/2016/29286
- Views 50
- Downloads 0
Phytochemical Study, Chemicalphysical Analysis and Toxicological Testing of Stem Bark of Dalbergia monetaria L. f.
Aims: Assessing the phytochemical profile, physicochemical and toxicity of crude ethanolic extract of Dalbergia monetaria L. f. against Artemia salina L. Study Design: The study aimed to determine the major classes of se...
Hepatoprotective Activity of Macrotyloma uniflorum (Lam.) Verdc. Seeds Extracts Against Paracetamol Induced Hepatotoxicity in Wistar Albino Rats
Background: Macrotyloma uniflorum (Horse gram) seeds are used in Ayurvedic medicine for treating numerous health disorders including rheumatism, worm, conjunctivitis and piles. The seeds were boiled with water and used a...
Effect of Different Doses of Sitagliptin in Treatment of Experimentally Induced Colitis in Mice
Ulcerative colitis is a chronic, relapsing and progressive inflammatory bowel disease (IBD) characterized by diffused mucosal inflammation of the colon. DPP-IV inhibitors may provide a new treatment strategy for IBD. Thu...
Erythropoietic Effects of Eremomastax polysperma Leaf Extracts on Female Prepubertal and Pubertal Wistar Rats
This study assessed the erythropoietic effect of Eremomastax polysperma leaf extracts in female albino Wistar rats. Method: Twenty eight (28) female rats were divided into two major groups based on their weight and age....
Anti-oxidant and Antimicrobial Flavonoid Glycosides from Alstonia boonei De Wild Leaves
Aims: Alstonia boonei De Wild (Apocynaceae) leaves are used traditionally in several parts of West Africa (including Nigeria) and Asia for the treatment of various ailments such as rheumatic and muscular pains as well as...