Evaluation of C-Reactive Protein and Fibrinogen in Patients with Chronic and Aggressive Periodontitis: A Clinico-Biochemical Study
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 3
Abstract
Introduction: Periodontal disease is characterised by chronic infection and inflammation in periodontal tissues leading to destruction of alveolar bone with subsequent tooth loss. Periodontal infections are the result of an interaction between tooth associated microbial biofilms and the host defences. Periodontal pathogens can affect local and systemic immune and inflammatory responses. Aim: The aim of the present study was to evaluate serum C-Reactive Protein (CRP), plasma fibrinogen and peripheral blood levels in healthy subjects, chronic and aggressive periodontitis patients. Materials and Methods: A total of 55 subjects, 27 males and 28 females were selected for the study. Blood samples were taken from healthy controls (n=20) and patients with chronic periodontitis (n=20) and aggressive periodontitis (n=15). The periodontal status of each patient was assessed by recording Oral Hygiene Index-Simplified (OHI-S), Bleeding Index (BI), Probing Pocket Depth (PPD) and Clinical Attachment Level (CAL). The levels of serum CRP were measured using high sensitivity Enzyme Linked Immunosorbent Assay (ELISA) and levels of plasma fibrinogen were measured using Quantitative Immunoturbidimetric assay. Data description was done in the form of mean and standard deviation and analysis of data was done using one way ANOVA (Analysis of Variance) and Students t-test to test the statistical significance between groups. Results: The levels of serum CRP and plasma fibrinogen was increased in patients with chronic and aggressive periodontitis when compared to healthy controls (p<0.001). A positive correlation was found to exist between levels of clinical parameters like OHI-S, BI, PPD and CAL when compared with CRP and fibrinogen as well as with the study groups. Conclusion: The finding of the present study suggests the role of serum as a diagnostic marker in inflammatory conditions and indicates that levels of CRP and fibrinogen may serve as important biomarkers for evaluating the association between periodontitis and cardiovascular diseases.
Authors and Affiliations
swaroop chandy, Kiran Joseph, Anila sankaranarayanan, Annie Issac, George Babu, Bobby wilson, jumol joseph
Keywords
Related Articles
- EP ID EP336759
- DOI 10.7860/JCDR/2017/23100.9552
- Views 111
- Downloads 0
Evaluation of Efficacy of Intravenous Iron Sucrose in Management of Adolescent Iron Deficiency Anaemia
Introduction: Worldwide, most common nutritional deficiency anaemia is iron deficiency anaemia. Anaemia in adolescent girls is defined as blood haemoglobin (Hb) level <12g/dL. The highest prevalence seen in ages of 14-19...
A Comparative Study of High Sensitivity C-Reactive Protein and Metabolic Variables in Type 2 Diabetes Mellitus with and without Nephropathy
Introduction: Diabetic nephropathy is a serious chronic complication of Type 2 Diabetes Mellitus (T2DM) which impairs the quality of life, leading to increased morbidity and mortality. The high sensitivity C-reactive pro...
Stress Among Pregnant Women: A Systematic Review
ABSTRACT Introduction: Stress is a complex situation which is genetically determined pattern of response of the human physiology to a challenging situation. Persistent emotional neglect and constant stress response refle...
Varied Orbital Inflammations in Diabetics
ABSTRACT Orbital cellulitis is purulent inflammation of the cellular tissue of the orbit. It is one of the clinical emergencies which need early diagnosis and treatment, especially in diabetics and immunocompromised pati...
Castleman Disease Presenting with Cervical Adenopathy in a Four-Year-Old Girl: A Case Report and Review of Literature
Castleman Disease (CD) is an uncommon cause of cervical lymphadenopathy in paediatric age group. Only few cases have been reported from outside Indian Subcontinent so far in paediatric age group (≤18 years), presenting w...