Abstract

Objective: To assess the status of carbohydrate antigen 125 (CA-125) and other biochemical parameters in premenopausal and postmenopausal ovarian cancer patients. Methods: Total 64 cases, out of which 43 premenopausal and 21 postmenopausal ovarian cancer patients were included in the study. Twenty-five premenopausal and twenty postmenopausal age-matched healthy control subjects were selected. The variables collected were age, CA- 125, total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), blood sugar, adenosine deaminase (ADA) and vitamin E. The data was analyzed by using Statistical Package for the Social Sciences for Windows Version 16.0. Results: In premenopausal women, significant differences were noted for CA-125 (P<0.005), triglycerides (P<0.009), HDL-C (P<0.001 ), blood sugar (P<0.001 ) and ADA (P<0.002) and in postmenopausal women, significant differences were noted for CA-125 (P<0.001), triglycerides (P<0.001), blood sugar (P<0.001), ADA (P<0.005) and vitamin E (P<0.002) when compared with controls. Insignificant results were found for total cholesterol (P=0.100), LDL-C (P=0.104) and vitamin E (P=0.142) in premenopausal women and total cholesterol (P=0.670), HDL-C (P=0.472) , LDL-C (P=0.272) in postmenopausal women when compared with healthy control subjects. Conclusions: Evaluation of CA-125 and other biochemical parameters may be important for control of ovarian cancer and to improved survival rate.

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