Evaluation of Cardiac Troponin I and CK-MB in Sudanese Patients with Acute Coronary Syndrome
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2015, Vol 3, Issue 3
Abstract
The objective of the study was to estimate levels of cardiac troponin I and CK-MB in patients with acute coronary syndrome. A total of 70 patients categorized according to ECG results to non-ST elevation myocardial infarction (NSTEMI) or ST myocardial infarction (STEMI) patients or unstable angina (UA). 5.0 ml of venous blood samples were collected and separated to obtain serum for estimation of serum troponin I and CK-MB. The mean values of CK-MB and cTnI were 65.0 ±10.4 and 6.5 ± 8.2, respectively. 32.1% of patients with UA show elevated CK-MB (> 25 U/L) while 96.6% of patients with STEMI and 83.3% show elevated levels of CK-MB. cTnI seen elevated (>1.5 ng/ml) as follows: 3.5 % in patients with UA, 96.6% in patients with STEMI, and 50% in patients with NSTEMI. From the results of this study and previous studies, no available biomarker offers ideal diagnostic properties for ACS, such as early detection, high sensitivity and specificity, easy availability, and cost effectiveness. But cTnI and CK-MB with ECG were with sufficient sensitivity and specicifity in diagnosis of STEMI patients. Keywords: ACS, cTnI, CK-MB, STEMI, Unstable angina
Authors and Affiliations
Israa M. Elmahdi, AbdElkarim A. Abdrabo
Keywords
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