Evaluation of cardioprotective activity of Pandanus odoratissimus leaves against isoproterenol induced myocardial infarction in albino rats
Journal Title: International Journal of Novel Trends in Pharmaceutical Sciences - Year 2014, Vol 4, Issue 5
Abstract
Cardiotoxicity is the occurance of heart electrophysiological dysfunction or muscle damage.In the present study Pandanus odoratissimus was used as Cardioprotective agent against Isoproterenol induced Myocardial Infarction in albino rats. The Hydro-alcoholic extracts of Pandanus odoratissimusleaves were prepared, animals were divided into 5 groups of 6 animals each. Group-I serves as a control and receives normal saline. Group-II serves as disease Control and receives Isoproterenol 85mg/kg s.c for two consecutive days (14th& 15th day). Group-III receives Atenolol -10mg/kg i.p, Isoproterenol-85mg/kg s.c, for 15 days. Group-IV and Group-V animals receives the Hydro-alcoholic extracts of Pandanus odoratissimus at doses an of 200mg/kg p.o and 400mg/kg p.o along with Isoproterenol (85mg/kg on s.c) for 15 days. Preliminary phytochemical analysis revealed the presence of various active constituents.Alterations in the biochemical parameters such as CAT, CK-MB, LDH, LPO and antioxidant levels such as GSH, SOD in tissue homogenate due to administration of Isoproterenol were studied.Finally the defense action against the cardiotoxicity produced by Isoproterenol by P.odoratissimus was supported by histopathological studies.
Authors and Affiliations
K. Sobhana , G. Vengal Rao , K. Nirosha , A. Ravikumar , RR. Sravanthi , P. Chandrkala
Keywords
Related Articles
- EP ID EP96346
- DOI -
- Views 91
- Downloads 0
Isolation and screening of alkalophilic actinobacteria, for biosynthesis and characterization of silver nanoparticles
The present study reports the extracellular biosynthesis of silver nanoparticles by alkalophilic Streptomyces species and its characterization. The biological synthesis would be beneficial because the development of cle...
Method development and validation of RP-HPLC Method for determination of new Antipsychotic agent in Paliperidone Palmitate bulk drug
A simple, precise, rapid ,reproducible, accurate and stability indicating RP-HPLC method has been developed for the determination of new antipsychotic agent paliperidone in pharmaceutical formulation. zorbax –SB-phenyl...
Hepatoprotective activity of ethanolic extract of leaves of Soymida febrifuga A.Juss. on paracetamol induced liver toxicity in rats
The objective of this study was to investigate the hepatoprotective activity of ethanolic extract of Soymida febrifuga (EELSF) leaves against paracetamol induced hepatotoxicity in Albino wistar rats. The plant material w...
Protein molecular motif comparison studies on Lung and Colon cancer genes (CHRNA3 and MLH1) using In-silico protocols
Worldwide, lung cancer is the most common cancer among men in terms of both incidence and mortality, and among women has the third highest incidence, and is second after breast cancer in mortality. In 2012, there were 1....
Phytochemical screening and in vitro antimicrobial activity of various extracts of Phyllanthus amaraus
Medicinal plants play a key role in the human health care. Phyllanthus amaraus is an economical plant and posess Anti-microbial activity. About 80% of the world Population relies on the use of traditional medicine which...