EVALUATION OF CARDIOTONIC ACTION OF ETHANOL EXTRACT OF LAGENARIA SICERARIA PULP ON FROG’S HEART
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2014, Vol 5, Issue 6
Abstract
The aim of this study is to the Herbal remedies are used worldwide for various diseases. They are safer and less expensive with lesser side effects than synthetic drugs. Lagenaria siceraria, the vegetable gourd, belonging to the family Cucurbitaceae is used as diuretic, cardio-tonic, cardio-protective and nutritive agent and traditionally in the treatment of jaundice, diabetes, ulcer, piles, colitis, insanity, hypertension, congestive cardiac failure and skin diseases. The present study was carried out to evaluate the cardiotonic effect of ethanol extract of pulp of Lagenaria siceraria (EELSP) in Amphibians such as the grass frog Rana pipiensin. After toxicity evaluation in albino rats two doses of the ethanol extract of Lagenaria siceraria pulp extracted with 90 % methanol using a Soxhelts apparatus was selected for the experiment. One grass Rana pipiensin frogs were taken and double pitching was done. Frog heart in situ was setup following standard procedures. Frog’s ringer, Acetyl choline, Adrenalin and ¼th Ca followed by two doses of EELSP was given one after the one and the graphing was recorded. The extract at 400 mg and 800 mg produced significant cardiotonic action. Thus the study elucidates that ethanol extract of Lagenaria siceraria pulp possess cardiotonic action at the doses of 400 and 800 mg.
Authors and Affiliations
Jayasree Tirumalasetti, Harini K. , Vinay Kumar, Rambabu Kondreddy , Shankar J.
Keywords
Related Articles
- EP ID EP162818
- DOI 10.7897/2230-8407.050699
- Views 106
- Downloads 0
ANTIOXIDANT EFFECT OF ARTEMISIA VULGARIS LEAF EXTRACTS ON OXIDATIVELY STRESSED PRECISION-CUT LIVER SLICES
Oxidative stress results from an excessive production of reactive oxygen species beyond the body’s antioxidant capacity. The overproduction of reactive oxygen species can lead to damage to cellular biomolecules, which is...
A STUDY ON COMORBIDITIES AND LIFE STYLE ASSOCIATED WITH DIABETES PATIENTS
The present study focused on the co morbidities and lifestyle associated with diabetes patients. It was a non experimental prospective study and done in outpatient department of endocrinology, Amrita Institute of Medica...
STUDY OF KRIMIGHNA EFFECT OF NIMBA (AZADIRACTA INDICA A.JUSS.) PATRA AS RAKSHOGHNA DHOOPAN BY CULTURE AND SENSITIVITY METHOD W.S.R. TO PYOGENIC BACTERIA
Nimbapatra (Azadiracta indica A.juss) is described as Krimighna in Ayurvedic literature. In the present study Pyogenic bacteria i.e. Staphylococcus aureus and Streptococcus pyogenus were grown on artificial media in labo...
COMPARISON STUDY BETWEEN IN-HOUSE IGM DOT-ELISA AND THE MICROSCOPIC AGGLUTINATION TEST (MAT) FOR THE DIAGNOSIS OF HUMAN LEPTOSPIROSIS
An indirect enzyme-linked immunosorbent assay (ELISA) was compared with the microscopic agglutination test (MAT) for the diagnosis of bovine leptospirosis. Blood samples from a total number of 319 HBsAg negative suspect...
A REVIEW ON THE THERAPEUTIC POTENTIALS OF PARTHENOLIDE: A SESQUITERPENE LACTONE
Medicinal plants have been widely employed in treating various diseases for centuries and are still a major resource and repository that can be further exploited for a variety of infectious and non-infectious ailments. T...