Evaluation of Clinical Profile and Hematological Parameters of Cases of Megaloblastic Anemia
Journal Title: National Journal of Community Medicine - Year 2017, Vol 8, Issue 10
Abstract
Background: Megaloblastic anemia is not uncommon in India. In India, the most common cause of megalo-blastic anemia is nutritional where as it is the pernicious anemia in Northern Europe. Aims and objectives: To study age and gender-wise distribution, diet patterns, clinical features and he-matological parameters in patients with megaloblastic anemia. Material and methods: This was an observational cross-sectional study of the hundred patients of megalo-blastic anemia. We included pa-tients having anemia with MCV>100 fL, serum vitamin B12 level <250 pg/ml and/ or serum folic acid level<3 ng/ml with nor-mal serum ferritin level were in-cluded. Detailed history, physical examination, laboratory parameters and radiological investigation were done. Results: Megaloblastic anemia is most common in age between 20-40 years of age. Male subjects were commonly affected. Most of the pa-tients (69%) belong to lower socio-economic class. 50% patients had severe anemia (Hb<7 gm %). Cobal-amin deficiency was responsible for megaloblastic anemia in the majori-ty of patients. Conclusion: Megaloblastic anemia has wide clinical & hematological spectrum. The most common symp-toms observed were a generalized weakness (98%), easy fatigability (96%), anorexia (64%) which is non-specific, so high degree of suspicion is required to diagnose megalo-blastic anemia.
Authors and Affiliations
Hemang N. Suthar, Tejas Shah
Keywords
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