Evaluation of clinicopathological parameters and its relation with immunohistochemical expressions in breast carcinoma: A hospital based cross-sectional observational study
Journal Title: IP Journal of Diagnostic Pathology and Oncology - Year 2018, Vol 3, Issue 4
Abstract
Introduction Knowhow of HER2neu protooncogene amplification andor over expression and presence of hormone estrogen and progesterone receptors in tumour tissue is one of the most crucial checkpoints in the therapy of breast cancer The present study aimed to evaluate various clinicopathological parameters in the mastectomy specimens and to probe for any relation with its immunohistochemical expressionsMaterials and Methods Detailed clinical examination of the breast and the lump was done and presence of any axillary or cervical lymph nodes was also noted After clinical examination tumour size from the mastectomy specimen was recorded number of lymph nodes was noted The modified radical mastectomy samples after surgical removal were fixed in formalin and sent for histopathological examination where tissue processing and staining with haematoxylin eosin was done Post mastectomy grading of the malignant breast lesion was done Immunostaining of the HER2 protein Estrogen receptors ER Progesterone receptors PR was performed for all specimensResults The present study showed a significant inverse association between ER and PR expression and higher tumour grades axillary lymph node metastases and stage HER2neu overexpression is significantly associated with clinicopathlogical parameters like younger age group increased tumour size higher tumour grades and higher clinical staging Significant association was seen between tumour size and lymph node metastases implying that lymph node metastasis increases with larger tumour sizeKeywords Breast Carcinoma HER2Neu receptor Estrogen Receptor Progesterone Receptor
Authors and Affiliations
Karabi Konar, Mala Mukherjee, Arghya Bandopadhyay, Shatavisa Mukherjee, Nikhil Era
Keywords
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- EP ID EP482797
- DOI 10.18231/2581-3706.2018.0063
- Views 119
- Downloads 0
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