Evaluation of Clonidine and Lignocaine for Attenuation of Haemodynamic Response to Laryngoscopy and Intubation: A Randomised Controlled Trial
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 2
Abstract
ABSTRACT Introduction: Laryngoscopy and intubation leads to stimulation of the laryngopharyngeal and tracheal structures which leads to reflex sympathetic response and sudden rise of Blood Pressure (BP) and Heart Rate (HR). This sudden rise, particularly in patients with cardiovascular and cerebrovascular diseases, can lead to precipitation of Myocardial ischaemia or heart failure. Drugs like fentanyl, esmolol, lignocaine, clonidine when given before the procedure can blunt this reflex, but their response varies widely. Aim: To compare the efficacy of lignocaine and clonidine in attenuating BP and HR response to intubation. Materials and Methods: The study was a double-blind randomised controlled trial was conducted in Operation Theatre (OT) of Indian Spinal Injuries Centre, New Delhi, India (between March 2009 to April 2011). After taking an informed consent, 105 patients of American Society of Anaesthesiologists (ASA) Grade I and II were randomised into three groups: a) Lignocaine; b) Clonidine and c) control group with Normal Saline (NS) and outcome of 90 patients was noted. The drugs were given by IV route before induction of anaesthesia and vital parameters before and after intubation were noted. An anaesthesiologist who was blinded to the study drugs for each group gave the drugs. Statistical analysis was done using Paired t-test, ANOVA, Duncan’s multiple range test. Significant p-value was considered less than 0.05. Results: The rise in BP and HR from baseline to one minute after intubation, was significantly less in both lignocaine and clonidine groups, as compared to the control. Conclusion: Both lignocaine and clonidine can be used to attenuate the haemodynamic response however, lignocaine seems to be better in maintaining vitals around baseline level and rise and fall of BP and HR is less.
Authors and Affiliations
Abhinav Gupta
Keywords
Related Articles
- EP ID EP522289
- DOI 10.7860/JCDR/2018/31728.11201
- Views 19
- Downloads 0
Newer v/s Classical Anthropometric Indices as a Screening Tool for Dyslipidemia in Healthy Young Adults
Introduction: The association of obesity with higher rates of dyslipidemia and cardiovascular diseases has been well documented. The most commonly used classical anthropometric indices do not provide an accurate distinct...
Pigmented Trichoblastoma of Nose: An Unusual Occurrence
Nevus sebaceus of Jadassohn is a congenital tumour affecting the scalp and face. It is usually presented as a pigmented patch or plaque. It is a complex cutaneous hamartoma which involves pilosebaceous follicle, epidermi...
Effect of Upper Limb Neural Mobilization on Vibration Threshold and Hand Grip Strength in Asymptomatic Individuals: A Randomized Controlled Trial
Introduction: Neural Tissue Mobilization (NTM) is a common technique used in clinical presentation with increased neural mechanosensitivity and was found to improve signs and symptoms. However, there is dearth in the lit...
A Morphological and Morphometric Study on Meniscofemoral Ligaments of Knee Joint and its Variations
ABSTRACT Introduction: There are two Meniscofemoral Ligaments (MFLs) in the knee joint, anterior Meniscofemoral Ligament (aMFL) and posterior Meniscofemoral Ligament (pMFL) named according to their position relative to P...
Effectiveness of a Teacher Training Workshop: An Interventional Study
ABSTRACT Introduction: There is an increasing demand upon medical school faculty to be effective teachers. Faculty development is an important component in medical education, for the institutes to excel. Pre test/post-t...