Evaluation of CNS Depressant, Antidiarrheal and Antipyretic Activities of Ethanolic Leaf Extract of Calophyllum inophyllum L. on Swiss Albino Mice
Journal Title: Journal of Advances in Medical and Pharmaceutical Sciences - Year 2017, Vol 12, Issue 2
Abstract
Objective: The main objective of the present study was to evaluate the CNS depressant, antidiarrheal and antipyretic activities of ethanolic leaf extract of Calophyllum inophyllum L. Methods: In the present study CNS depressant activity of C. inophyllum was carried out using hole-cross, hole-board and open-field models in swiss albino mice whereas castor-oil induced diarrhea was used to evaluate antidiarrheal activity. The antipyretic activity was conducted by Brewer’s yeast-induced hyperthermia in mice. Results: The experimental result indicates that the ethanolic extract of C. inophyllum induced CNS depression significantly (p<0.05) in tested animals and the observed effect was dose dependent comparable to standard drug diazepam. The plant extract at the dose of 250 and 500 mg/kg body weight showed significant inhibition of 41.66% and 62.19% in castor oil-induced diarrheal method. In yeast-induced pyrexia, the plant extract displayed dose-dependent inhibition as compared to paracetamol. Conclusion: This study concludes that C. inophyllum leaf has significant CNS depressant, antidiarrheal and antipyretic activities which provide scientific support for its medicinal applications.
Authors and Affiliations
Seuly Akter, Md. Saddam Hossain, Md. Rubel Mia, Md. Shahid Sarwar
Keywords
Related Articles
- EP ID EP311597
- DOI 10.9734/JAMPS/2017/29994
- Views 96
- Downloads 0
Pain Assessment and Treatment in Pediatric Patients
Although there are a considerable number of pain assessment scales, only some of them can be used for practical intentions. The Faces Pain Scale is used for children 4 to 6-7 years old, while the Visual Analog Scale (VAS...
Chemical Evaluation, Free Radical Scavenging Activities and Antimicrobial Evaluation of the Methanolic Extracts of Corn Silk (Zea mays)
Corn silk is thought to possess medicinal properties according to Nigerian folklore. This study was undertaken to appraise its phytochemical constituents and anti-microbial activities. Data obtained revealed that alkaloi...
A Practical Approach for Restoring Homeostasis in Diseases Characterized by a Chronic Oxidative Stress
The leading cause of death across the globe is due to cardiovascular diseases complicated by a chronic oxidative stress only partially corrected with orthodox drugs. About 80% of deaths occur in low and middle-income cou...
Placenta Percreta and Its Consequences: A Case Report
Severe hemorrhage during delivery may lead to complications if the urinary bladder is involved in cases of placenta percreta. If placenta percreta and its complications are discovered during delivery, they might be able...
Effects of Administration of Methanol Root Bark Extract of Cussonia arborea on Serum Biochemical Markers of Kidney Damage and Renal Histomorphology of Alloxan-induced Diabetic Rats
Aim: This study evaluated the effects of oral administration of varied doses of methanol root bark extract of Cussonia arborea on some serum biochemical markers of kidney damage and renal histomorphology of alloxan-induc...