Evaluation of Cyclosporine A with β-TCP in the Treatment of Human Infra bony Defects – A Randomized Controlled Pilot Study
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 1
Abstract
Introduction: Cyclosporine A (CsA), an immunosuppressant, is considered a life saver drug in organ transplant cases. It has also been tested in animal and human studies for periodontal applications as it selectively inhibits T lymphocyte proliferation, Interleukin-2 (IL-2) and other cytokine production, without any effect on T suppressor cells, thereby suppressing the cell mediated immunity and suppressing the inflammation. Inflammatory and immunological responses have been found to be decreased and bone formation is found to be increased in immunosuppressed animals. CsA is also supposed to potentiate osseous regeneration due to increase in the bone alkaline phosphatase levels and a direct activating effect on osteoblasts. Aim: The present study was aimed at evaluating locally administered low dose of CsA which is potent immunosuppressant along with β-Tricalcium phosphate (β-TCP) in comparison with β TCP alone, in the treatment of human infrabony defects, over a period of six months. Materials and Methods: Thirty two systemically healthy chronic periodontitis patients with infrabony defects were included in the randomized, controlled, parallel arm study and were allocated into either Group A (n =16), patients treated with β-TCP + CsA (2 mg) or Group B (n =16), patients treated with β-TCP. Clinical parameters [Relative Attachment Level (RAL), Probing Depth (PD), Gingival Recession (GR)] and radiographic parameters were measured at baseline and six months postoperatively. Statistical analysis was done using SPSS version 16 software. Student’s paired and independent t-test were used for intra and inter-group analysis. Results: Both Group A and Group B showed statistically significant improvements in clinical and radiographic parameters from base line to six months post-operatively. The Clinical Attachment Level (CAL) gain, Linear Bone Growth (LBG) and Percentage Bone Fill (% BF) were 2.38±1.12 mm, 1.90±1.48 mm and 49.83±29.23 mm in Group A and 2.57±1.22 mm, 2.03±1.16 mm and 62.84±29.70 mm in Group B respectively, inter group comparison showed no statistically significant difference. Conclusion: Both the groups revealed statistically significant improvement in clinical and radiographic parameters and adjunctive use of CsA did not prove beneficial.
Authors and Affiliations
Jyotsna Amalakara, Krishnajaneya Reddy, Haritha Avula, Ashank Mishra, Butchibabu Kalakonda, Ruchi Pandey
Keywords
Related Articles
- EP ID EP328962
- DOI 10.7860/JCDR/2017/23365.9194
- Views 131
- Downloads 0
Prevalence of Metabolic Syndrome among Psychiatric Inpatients: A Hospital Based Study from Kashmir
Introduction: Over the last fifty years there has been dramatic change in the human environment, behaviours and way-of-life. These changes have resulted in escalating rates of metabolic syndrome not only in general popul...
Rising Incidence of Non-albicans Candida and Changing Susceptibility Pattern of Bloodstream Candida Isolates in Neonates
Introduction: Importance of Candida species in nursery and paediatric Intensive Care Units (ICUs) is increasingly being recognized and nowadays isolates resistant to antifungal therapy are on the rise. They account for 9...
Cystic Sertoli-Leydig Cell Tumour in a Postmenopausal Woman with Absent Virilising Symptoms: A Diagnostic Challenge
A 60-year-old postmenopausal woman, presented with a left ovarian cystic mass with mildly elevated CA125 levels. An intraoperative frozen section showed oedematous ovarian stroma with interspersed large aggregates of spi...
Psychiatric Counsellors Experience of Caring for Schizophrenic Patients at Psychiatric Nursing Home
ABSTRACT Introduction: Schizophrenia is a grave mental illness, that hampers a person’s ability to think clearly, manage emotions, make decisions and relate to others. Counsellors are the primary care giver of the patien...
Improved Outcome with Gefitinib in Recurrent Middle Ear Squamous Cell Carcinoma
Middle ear and external ear malignancies are rare. There is lack of consensus in managing such cases. Surgery followed by radiotherapy is the best option for advanced cancers, while radiotherapy alone in radical doses is...