EVALUATION OF CYTOTOXIC AND MEMBRANE STABILIZING ACTIVITIES OF GREWIA ABUTILIFOLIA LEAVES
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2017, Vol 4, Issue 11
Abstract
The aim of the project was to evaluate the cytotoxic and membrane stabilizing activities of the leaves of Grewia abutilifolia (Family-Tiliaceae). The crude methanolic extract of the leaves of Grewia abutilifolia and its different Kupchan fraction were screened for cytotoxic and membrane stabilizing activities. In Brine shrimp lethality bioassay the most potent activity was found in Chloroform fraction and showed the higher level of cytotoxicity. The ED50 value of CLF was 90.90mg/ml. Membrane stabilization is the method through which the local anesthetics work. This membrane stabilization was done by using erythrocyte in hypotonic solution which was compared with the acetyl salicylic acid. In hypotonic solution induced conditions, the extract of Grewia abutilifolia, were found to inhibit lysis of erythrocyte membrane within the range of 95.67±0.25% to 99.50±0.034%. The Chloroform extract of Grewia abutilifolia showed high inhibition (99.50±0.034%) hemolysis of RBC as compared to 96.58±Description:3.56 revealed by acetyl salicylic acid. The Summary of in vitro study represent that Grewia abutilifolia exhibits cytotoxicity and membrane stabilizing activity.
Authors and Affiliations
Md. Ibrahim Sunny
Keywords
Related Articles
- EP ID EP630387
- DOI -
- Views 142
- Downloads 0
DETERMINING THE RELATIONSHIP BETWEEN THE LEVEL OF OXYTOCIN IN HUMAN BLOOD AND POSTPARTUM DEPRESSION (PPD) IN PREGNANT WOMEN REFERRING TO GOVERNMENTAL HOSPITALS AFFILIATED TO AHWAZ UNIVERSITY OF MEDICAL SCIENCES IN 2015
Introduction: Postpartum depression (PPD) affects approximately 19% of women. According to the DSM-5™ Diagnostic Criteria, postpartum depression is a component of major depressive disorder that is diagnosed during pregna...
FORMULATION DEVELOPMENT AND EVALUATION OF OXYMORPHONE HCL SOFT GELATIN CAPSULES
The objective of this work is to develop simple, elegant, liquid-filled immediate release soft gelatin capsules containing Oxymorphone HCl intended for the management of moderate to severe pain in patients who require tr...
TREND OF KARACHITTIES TOWARDS HOMOEOPATHIC SYSTEM OF TREATMENT: A CROSS-SECTIONAL STUDY
The purpose of the study was to evaluate the inclination of Karachi population towards homoeopathic system of treatment and to justify its safety and efficacy. Patients were interviewed and feedback forms were got filled...
SERUM CORTISOL AND CORTICOTROPIN LEVELS AMONG HYPERTENSIVE PATIENTS IN KANO, NIGERIA
Hypertension remains the leading single cause of morbidity and mortality worldwide, and a growing public health problem in sub-Saharan Africa (SSA). Few studies have estimated serum cortisol and corticotrophin (ACTH) lev...
CLINICAL OUTCOMES OF POSTERIOR FOSSA TUMOR SURGERY WITHOUT PREOPERATIVE VENTRICULAR-PERITONEAL SHUNT
The aim of the study was to assess the clinical outcome of surgically treated patients with posterior fossa tumor with hydrocephalus with symptoms and signs of raised intracranial pressure without pre-operative ventricul...