Evaluation of directly measured LDL-Cholesterol in Assessing the Cardiovascular Risk Defined by Total Cholesterol/HDL-Cholesterol Ratio
Journal Title: UNKNOWN - Year 2016, Vol 5, Issue 1
Abstract
Introduction: Commonly, LDL-cholesterol levels are estimated indirectly by Friedewald equation and called as calculated LDL (cLDL). Assays for direct determination of LDL-C have come into vogue to overcome the limitations of Friedewald equation and are called as direct LDL-C (dLDL). The total cholesterol to High Density Lipoprotein cholesterol (TC: HDL-C) ratio is a powerful predictor of cardiovascular disease (CVD). Therefore, this study was undertaken to evaluate dLDL in assessing CVD risk defined by the TC: HDL-C rati. Materials and Methods: The lipid profile data of 734 patients with triglyceride values between 100 and 400 were obtained. Patients were grouped and analysed on the basis of TC: HDL-C ratio cut-off. Results: This study showed dLDL values were significantly increased in CVD risk groups defined by TC: HDL-C ratio. Study also revealed that dLDL values were more than the cLDL values and hence identified more number of CVD risk individuals compared to cLDL. Directly measured LDL had high specificity and calculated LDL had high specificity. TC: HDL-C ratio and dLDL identified more number of CVD risk individuals. Conclusion: LDL-C measured by direct method not only assesses CVD risk defined by the TC: HDL-C ratio but also identifies more number of CVD risk individuals when compared to cLDL.
Authors and Affiliations
Krishnamurthy U, Banerjee P
Keywords
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