Evaluation of directly measured LDL-Cholesterol in Assessing the Cardiovascular Risk Defined by Total Cholesterol/HDL-Cholesterol Ratio
Journal Title: International Journal of Medical and Health Sciences - Year 2016, Vol 5, Issue 1
Abstract
Introduction: Commonly, LDL-cholesterol levels are estimated indirectly by Friedewald equation and called as calculated LDL (cLDL). Assays for direct determination of LDL-C have come into vogue to overcome the limitations of Friedewald equation and are called as direct LDL-C (dLDL). The total cholesterol to High Density Lipoprotein cholesterol (TC: HDL-C) ratio is a powerful predictor of cardiovascular disease (CVD). Therefore, this study was undertaken to evaluate dLDL in assessing CVD risk defined by the TC: HDL-C rati. Materials and Methods: The lipid profile data of 734 patients with triglyceride values between 100 and 400 were obtained. Patients were grouped and analysed on the basis of TC: HDL-C ratio cut-off. Results: This study showed dLDL values were significantly increased in CVD risk groups defined by TC: HDL-C ratio. Study also revealed that dLDL values were more than the cLDL values and hence identified more number of CVD risk individuals compared to cLDL. Directly measured LDL had high specificity and calculated LDL had high specificity. TC: HDL-C ratio and dLDL identified more number of CVD risk individuals. Conclusion: LDL-C measured by direct method not only assesses CVD risk defined by the TC: HDL-C ratio but also identifies more number of CVD risk individuals when compared to cLDL.
Authors and Affiliations
Banerjee P, Krishnamurthy U
Keywords
Related Articles
- EP ID EP39935
- DOI -
- Views 259
- Downloads 0
Effect of Moderate Intensity Aerobic Exercises on Vital Capacity And Quality of Life on Asymptomatic Subjects With Sedentary Lifestyle
Background: The present study is designed to determine if vital capacity can predict quality of life as well as document the effect of aerobic exercise on vital capacity. Materials And Methods: An experimental study. Pa...
Effect of Pharmacological treatment on cardiac biomarkers in patients with acute coronary syndrome of non–ST segment elevation with Type-2 diabetes
Background: The acute coronary syndrome is a consequence of coronary artery disease. Creatine Kinase MB is a cardiac biochemical marker used in the diagnosis and risk stratification of patients. The diabetes is a pathol...
Is Socioeconomic Status an Important Predictor of Alcohol use?: A cross-sectional study in an urban slum of Meerut
Background: Of all addictions like opiods, cannabinoids, sedatives, cocain, caffeine,hallucinogens, tobacco and other psychoactive drugs, it is the addiction to alcohol that remains the most important. Perhaps, this is...
Changes In Anthropometric And Lipid Proifle In Healthy Young Offsprings Of Diabetics Are Not Temporally Linked
Diabetes mellitus (DM) is an emerging public health concern. Offspring’s of diabetics are known to express various trait characteristics. In the present study, anthropometric and metabolic parameters among healthy offs...
Otomycosis : A Clinico Mycological Study
Introduction: Otomycosis is a common fungal infection of the ear that is seen in the tropical and sub tropical regions of the world. Objective: The aim of this study was to determine the prevalence of fungal agents and...