Evaluation of Diuretic Activity of aqueous extract of Ipomoea batatas (L)
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2016, Vol 4, Issue 6
Abstract
Abstract: A diuretic is any substance that promotes the production of urine. This includes forced diuresis. There are several categories of diuretics. All diuretics increase the excretion of water from bodies, although each class does so in a distinct way. Alternatively, an ant diuretic such as vasopressin, or ant diuretic hormone, is an agent or drug which reduces the excretion of water in urine. In medicine, diuretics are used to treat heart failure, liver cirrhosis, hypertension, influenza, water poisoning, and certain kidney diseases. Some diuretics, such as acetazolamide, help to make the urine more alkaline and are helpful in increasing excretion of substances such as aspirin in cases of overdose or poisoning. Diuretics are often abused by those with eating disorders, especially bulimics, in attempts to lose weight. The antihypertensive actions of some diuretics (thiazides and loop diuretics in particular) are independent of their diuretic effect. That is, the reduction in blood pressure is not due to decreased blood volume resulting from increased urine production, but occurs through other mechanisms and at lower doses than that required to produce diuresis. Indapamide was specifically designed with this in mind, and has a larger therapeutic window for hypertension (without pronounced diuresis) than most other diuretics. The main objective of the present research work is to isolate the bioactive molecules and evaluate the diuretic activity of aqueous extract of Ipomoea batatasthe phytochemical analysis of aqueous extract of Ipomoea batatas root showed the presence of various phytochemical constituents such as flavonoids, carbohydrates, tannins, phenol. The effect of aqueous extract of root of Ipomoea batatas on rats with reference to biochemical changes in serum. The group-II (Standard Hydrochlorothiazide 10 ml/kg, p. o) animals showed significant (P<0.01) increase in total urine volume ml/100 gm/hr (10.44 ml). Whereas animals received AEIB significantly (P<0.01) increase in total urine volume ml/100 gm/hr (4.44 and 8.06 ml) and significantly (P<0.05) increased total 200 & 400 mg/kg doses respectively. The results of most several clinical investigations showed the efficacy and safety of carbohydrate, flavonoids are using diuretic activity give a fine action comparative standard drugs. The phytochemical studies revealed the presence of Carbohydrate, flavonoids, Tannins in the AEIB these may be responsible for its pharmacological activities. Keywords:Diuresis, vasopressin, hypertension, flavonoids etc
Authors and Affiliations
M. Sucharitha . , M. Kotesh . , K. Devika . , Y. Naresh . , M. Kiran .
Keywords
Related Articles
- EP ID EP370903
- DOI -
- Views 59
- Downloads 0
Comparison of Continuous Positive Airway Pressure Therapy with and Without Surfactant in Neonatal Respiratory Distress Syndrome
Neonatal respiratory distress syndrome is an important cause of morbidity and mortality in preterm neonates. Recognition of adverse effects related to mechanical ventilation, led researchers to explore various non-invasi...
Comparison of Serum Uric Acid Level and Coronary Artery Calcium Score
Abstract: The aim of the study was to evaluate the interrelation between serum uric acid and artery calcification in asymptomatic coronary artery disease subjects. Dialysis patients display an increased mortality which...
In-Vitro Sensitivities of Combinations of Cefipime, Ceftazidime, Cefpirome Along With Beta Lactamase Inhibitors Sulbactam against ESBL Producing Enterobacteriaceae
Abstract: ESBL (extended spectrum beta lactamase) producing enterobactericeae are resistant to betalactam group of antibiotics causing a great threat to their treatment options .The present study was undertaken to determ...
Disseminated subcutaneous Phaeohyphomycosis caused by Cladophialophora carrionii – Case Report
Abstract: Subcutaneous phaeohyphomycosis is chronic fungal infection of the skin & sub cutaneous tissuecaused by darkly pigmented (dematiaceous) fungi and included in Chromomycosis group along with Chromoblastomycosis. I...
Prevalance of Depression in Patients with ESRD on HD- A Cross Sectional Observational Study in a Teaching Hospital in Karnataka
To assess the prevalence of depression in patients on chronic hemodialysis and to evaluate the risk factors. 100 patients undergoing hemodialysis were included in this study. After obtaining ethical clearance and informe...