EVALUATION OF DIURETIC ACTIVITY OF MILK EXTRACT OF SEMECARPUS ANACARDIUM NUT
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 3
Abstract
Semicarpus anacardium ‘Marketing Nut’ is a tropical flowering plant widely distributed in India. Semicarpus anacardium are widely used for its therapeutic potential as immunomodulatory and in folklore the plant material is reported in the treatment of diuretic. Since, the diuretic activity of these plant materials has not been investigated in scientifically controlled studies; the aim of the present study was to evaluate the diuretic potential of milk extracts of Semicarpus anacardium seed in normal rats after acute and sub-chronic oral administration. Milk extracts of Semicarpus anacardium seed (150 and 300 mg/kg) along with the reference drug, furosemide (10 mg/kg) were administrated orally to male Wistar rats for 8 subsequent days and their urine output was quantitated at several intervals of time after the dose. Several other parameters such as urinary electrolyte concentration, plasma electrolyte concentration and creatinine clearance were also measured by flame spectrophotometry and Jaffe alkaline picrate method. After administration of single dose of the milk extracts of Semicarpus anacardium seed, urine output significantly showed equivalent increment at all time points, and at 24 h after the dose, the total volume of urine excreted was highest in furosemide followed by plant extracts and control group. Both extracts increased the urinary levels of Na+ and K+, to about the same extent, while furosemide increased urinary levels of only Na+ and decreased urinary K+. Despite changes in urinary excretion of the electrolytes, plasma Na+ and K+ levels were not affected by any of the substances. The present study supports the ethnomedical use of Semicarpus anacardium seed for their diuretic effect.
Authors and Affiliations
Dhirendra Prakash, M. C. Bindal, Santosh Gupta, A K Gupta, Vedpal
Keywords
Related Articles
- EP ID EP135745
- DOI 10.7897/2230-8407.04335
- Views 114
- Downloads 0
PRELIMINARY PHYTOCHEMICAL SCREENING OF DIFFERENT SOLVENT MEDIATED MEDICINAL PLANT EXTRACTS EVALUATED
Medicinal plants have bioactive compounds which are used to curing of various diseases. In this present investigation involves five different medicinal plants Cledrodendrum inerme, Dennotia tripetala, Pongamia glabra, O....
CHEMICAL AND PHYTOCHEMICAL ANALYSIS OF SOME ANTI DIABETIC PLANTS IN YEMEN
There are many hypoglycemic plants known through the folklore in Yemen and some of Arabic Countries. The study was carried out to analyze the nutritional composition, mineral content and phytochemicals of the seeds of Tr...
THERAPEUTIC AND NUTRITIONAL VALUES OF TAKRA (BUTTERMILK)
Takra (Buttermilk) is a dietary product and is being used by Ayurveda from centuries. Takra is a product obtained by curd (fermented product of milk). In Ayurveda the usefulness of Takra is mentioned in many topics like...
CLINICAL ASSESSMENT OF SUSHRUTOKTA DWADASHAVIDHA PARIKSHA IN MADHUMEHA
Present study was carried out to understand the strength (Rogibala) as well as to know the intensity of disease (rogabala) madhumeha (DM) by adopting Sushrutokta Dwadashavidha Pariksha. Present clinical study reveals tha...
STUDIES ON ANTIMICROBIAL ACTIVITY AND PHYTOCHEMICAL ANALYSIS OF CITRUS FRUIT JUICES AGAINST SELECTED ENTERIC PATHOGENS
The present study was carried out to find out the antimicrobial activity and phytochemical study of citrus fruit juices viz. Lemon (Citrus limon) and Orange (Citrus ourantium) against medically important selected enteric...