EVALUATION OF EARLY LYMPH NODE METASTASIS IN SQUAMOUS CELL CARCINOMA OF THE PENIS WITH THE AID OF p53 IMMUNOMARKER
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2019, Vol 6, Issue 11
Abstract
BACKGROUND Use of p53 as a prognostic marker to detect early lymph node metastasis in carcinoma of penis in order to avoid unnecessary lymphadenectomy was evaluated. The aim of the study is to detect early metastasis in amputated specimens of penis, by using p53 immuno marker, and correlation with the histopathological variables and clinical stage. MATERIALS AND METHODS Retrospective study of 49 cases of partial /total amputation with lymphadenectomy of penile cancers were divided into metastatic and non-metastatic groups on H&E sections in which 16/49 had metastasis. Histological slides from all cases were processed with immunohistochemical technique using anti‑p53 antibodies. The p53 tumour density was calculated in 100 cells with 20% cut off and was graded as positive when more than 20% of the tumour cells showed positive nuclear staining. All the pathological and clinical variables were calculated by chi square test. RESULTS 13/49 cases showed increased p53 tumour density, p-value of 0.05 was considered significant in our study. p53 did not correlate statistically with histopathological and clinical variables like phimosis, BXO, clinical node status, tumour type, tumour grade, depth of invasion, LVI. p53 had low positive predictive value. Therefore, in our study, p53 cannot predict the early lymph node metastasis because of low positive predictive value, even though they are sensitive. CONCLUSION p53 immunomarker had low specificity and low positive predictive value, which suggests that it is not able to predict early lymph node metastasis even though it is sensitive and thus it is not helpful in deciding for prophylactic lymphadenectomy.
Authors and Affiliations
Miriam Sandeep Eden, Ramani Kumar
Keywords
Related Articles
- EP ID EP615531
- DOI 10.18410/jebmh/2019/175
- Views 93
- Downloads 0
CLINICAL OUTCOME WITH ADD ON RACECADOTRIL VERSUS STANDARD CARE IN PAEDIATRIC GASTROENTERITIS – OUR EXPERIENCE
BACKGROUND Acute gastroenteritis (AGE) is a diarrheal disease of rapid onset, with an increase in the water content, volume, or frequency of stools and often self-limiting. The WHO recommends ORS as the treatment of choi...
PERIPHERAL BLOOD AND BONE MARROW FINDINGS IN LYMPHOMAS: A STUDY IN A TERTIARY CARE HOSPITAL
BACKGROUND Lymphomas are the common haematological malignancies encountered in clinical practice. Most of them present with enlarged lymph nodes and extra nodal presentation is a rare feature. All the lymphoma cases requ...
LIVER ABSCESS IN TRIBAL POPULATION OF SOUTH RAJASTHAN; MANAGEMENT BY SONOGRAPHY GUIDED PERCUTANEOUS TUBE DRAINAGE IN 61 CASES IN FOUR YEARS
Untreated, pyogenic liver abscess remains uniformly fatal. With timely administration of antibiotics and drainage procedures, mortality currently occurs in 5-30% of cases. The most common causes of death include sepsis,...
COMPARISON BETWEEN TRANSVERSE ABDOMINIS PLANE BLOCK VERSUS TRADITIONAL PARENTERAL ANALGESIA IN LOWER ABDOMINAL SURGERIES
BACKGROUND A revolution in the management of acute postoperative pain has occurred during the past three decades. The transverse abdominis plane block is a peripheral nerve block used to provide analgesia to anterior and...
RELATIONSHIP OF SLEEP DURATION AND QT INTERVAL IN OBESE AND NON-OBESE MEDICAL STUDENTS
BACKGROUND Sleep deprivation has become a major concern in the modern era. It is found to have an inverse relation with obesity increasing cardiovascular diseases. This study was done to correlate effects of sleep depriv...