Evaluation of Efficacy & Tolerability of Trisoliv® Syrup (Andrographolides + Tricholine Citrate + Sorbitol) in the Management of Various Liver Dysfunctions
Journal Title: INTERNATIONAL JOURNAL OF PHARMACY AND BIOLOGICAL SCIENCES - Year 2012, Vol 2, Issue 1
Abstract
Polyherbal drug formulations having hepatoprotective activity is the widely recognized and utilized therapy in the management of various liver dysfunctions. To evaluate efficacy and tolerability of Trisoliv® Syrup in the management of various liver dysfunctions. Open, non-comparative, multi-centre, post marketing study. 50 patients suffering from various liver dysfunction like were enrolled in this study, 46 patients completed the study. Patients were given hepatoprotective syrup containing Andrographolides + Sorbitol + Tricholine citrate (A + S + T) 10 ml 2 to 3 times in a day for 8 weeks. The subjective clinical improvement in (jaundice symptoms, fatigue, and loss of appetite) was assessed on a predefined 0 to 3 score scale. Total bilirubins (TB), SGOT/ AST, SGPT/ALT, serum alkaline phosphatase were assessed at baseline and end of 8 weeks. Secondary outcomes were patient’s assessment about efficacy and tolerability of the hepatoprotective product Trisoliv. After 8 weeks of Trisoliv Syrup therapy 86.96% (40/46) of patients achieved the normal values for TB. As like TB, there was significant improvement in SGOT values after treatment with Trisoliv Syrup. 100 % of patients achieved normal values for SGPT/ALT and alkaline phosphatase (AP) values after 8 week of Trisoliv Syrup therapy. All the patients reported significant improvement in Jaundice, fatigue and loss of appetite on predefined 0 to 3 score scale. On the predefined scale of global efficacy 86.96% patients reported good to excellent efficacy rating for Trisoliv Syrup. Similarly, 82.61% patients reported good to excellent ratings for tolerability. The result of the study showed that A + S + T (Trisoliv syrup) is clinically effective and safe in the management of various liver dysfunctions. KEYWORDS: Hepatitis, liver, bilirubin, SGOT, SGPT, Andrographis paniculata, sorbitol
Authors and Affiliations
Arif A. Faruqui 1*, Chandrakant Joshi 2, Wasim Siddique3, Rahul Mahajan 4
Keywords
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