Evaluation of Efficacy & Tolerability of Trisoliv® Syrup (Andrographolides + Tricholine Citrate + Sorbitol) in the Management of Various Liver Dysfunctions
Journal Title: INTERNATIONAL JOURNAL OF PHARMACY AND BIOLOGICAL SCIENCES - Year 2012, Vol 2, Issue 1
Abstract
Polyherbal drug formulations having hepatoprotective activity is the widely recognized and utilized therapy in the management of various liver dysfunctions. To evaluate efficacy and tolerability of Trisoliv® Syrup in the management of various liver dysfunctions. Open, non-comparative, multi-centre, post marketing study. 50 patients suffering from various liver dysfunction like were enrolled in this study, 46 patients completed the study. Patients were given hepatoprotective syrup containing Andrographolides + Sorbitol + Tricholine citrate (A + S + T) 10 ml 2 to 3 times in a day for 8 weeks. The subjective clinical improvement in (jaundice symptoms, fatigue, and loss of appetite) was assessed on a predefined 0 to 3 score scale. Total bilirubins (TB), SGOT/ AST, SGPT/ALT, serum alkaline phosphatase were assessed at baseline and end of 8 weeks. Secondary outcomes were patient’s assessment about efficacy and tolerability of the hepatoprotective product Trisoliv. After 8 weeks of Trisoliv Syrup therapy 86.96% (40/46) of patients achieved the normal values for TB. As like TB, there was significant improvement in SGOT values after treatment with Trisoliv Syrup. 100 % of patients achieved normal values for SGPT/ALT and alkaline phosphatase (AP) values after 8 week of Trisoliv Syrup therapy. All the patients reported significant improvement in Jaundice, fatigue and loss of appetite on predefined 0 to 3 score scale. On the predefined scale of global efficacy 86.96% patients reported good to excellent efficacy rating for Trisoliv Syrup. Similarly, 82.61% patients reported good to excellent ratings for tolerability. The result of the study showed that A + S + T (Trisoliv syrup) is clinically effective and safe in the management of various liver dysfunctions. KEYWORDS: Hepatitis, liver, bilirubin, SGOT, SGPT, Andrographis paniculata, sorbitol
Authors and Affiliations
Arif A. Faruqui 1*, Chandrakant Joshi 2, Wasim Siddique3, Rahul Mahajan 4
Keywords
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Evaluation of Efficacy & Tolerability of Trisoliv® Syrup (Andrographolides + Tricholine Citrate + Sorbitol) in the Management of Various Liver Dysfunctions
Polyherbal drug formulations having hepatoprotective activity is the widely recognized and utilized therapy in the management of various liver dysfunctions. To evaluate efficacy and tolerability of Trisoliv® Syrup in the...
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