EVALUATION OF EFFICACY AND SAFETY OF HIGH DOSE SECOND GENERATION NON - SEDATING ANTIHISTAMINES LEVOCETIRIZINE AND FEXOFENADINE IN CHRONIC URTICARIA - A PROSPECTIVE, PARALLEL, RANDOMIZED, SINGLE BLIND, COMPARATIVE STUDY.
Journal Title: IJSR-International Journal Of Scientific Research - Year 2018, Vol 7, Issue 2
Abstract
There are few studies with up dosing of different 2nd generation antihistamines. This study evaluates efficacy and safety of high doses of Levocetirizine and Fexofenadine in chronic urticaria. This study includes 24 patients with chronic urticaria. Initially Fexofenadine 180 mg or Levocetirizine 5 mg was started. Doses of study drugs were doubled at the end of 1 week and tripled at the end of 2 weeks in non-responders and continued up to 4th week. Patients completed 2 week treatment with highest doses were included in the analysis. All patients were evaluated for symptoms, VAS for sedation and critical flicker fusion threshold (CFFT) for coordination before and after study. Reduction in mean total symptoms score and CFFT were highly significant in Fexofenadine group. Conclusion: Fexofenadine is superior to Levocetrizine in high doses in reducing mean symptoms score and sedation and no impairment in coordination in patients with chronic urticaria.
Authors and Affiliations
D. Aruna, M. Padmaja, S. P. Vijayalakshmi
Keywords
Related Articles
- EP ID EP505795
- DOI -
- Views 44
- Downloads 0
AWARENESS OF MEDICAL STUDENTS AND INTERNS ABOUT RECENT CHANGE IN RNTCP GUIDELINE IN TUBERCULOSIS DIAGNOSIS AND MANAGEMENT
Tuberculosis control can signicantly be increased if more effort is given to improve knowledge and attitudes of physicians towards prevention and control of disease. This study aimed to assess the knowledge about recent...
A CLINICAL STUDY ON EXPECTANT MANAGEMENT VERSUS INDUCTION OF LABOUR IN TERM PREMATURE RUPTURE OF MEMBRANES
Premature rupture of membranes (PROM), also called Prelabour Rupture Of Membranes, is classically defined as rupture of membranes before labour and accounts for 0.8-0.9% of all pregnancies at term. is study was conducte...
CLINICAL PRESENTATION OF BREAST CANCER PATIENTS ATTENDING AT REGIONAL INSTITUTE OF MEDICAL SCIENCES, MANIPUR
Background: Increasing incidence of breast cancer has been a major health problem for women in Manipur. Knowledge of clinical presentation of patients with breast cancer may help in planning prevention, screening and tre...
TO STUDY THE ULTRASOUND-GUIDED PERCUTANEOUS ASPIRATION IN LACTATIONAL BREAST ABSCESSES: A HOSPITAL-BASED STUDY
Breast abscess is a common cause of morbidity in women. While they are less common in developed countries as a result of improved maternal hygiene, nutrition, standard of living and early administration of antibiotics, b...
A RETROSPECTIVE STUDY OF URINE CYTOLOGY SAMPLES AS PER THE PARIS SYSTEM
Background: The Paris system (TPS) for reporting urinary cytology was published in 2016 with the goal of standardization of reporting urine cytology. The primary objective of this exercise was early detection of high gra...