EVALUATION OF EFFICACY AND SAFETY OF HIGH DOSE SECOND GENERATION NON - SEDATING ANTIHISTAMINES LEVOCETIRIZINE AND FEXOFENADINE IN CHRONIC URTICARIA - A PROSPECTIVE, PARALLEL, RANDOMIZED, SINGLE BLIND, COMPARATIVE STUDY.
Journal Title: IJSR-International Journal Of Scientific Research - Year 2018, Vol 7, Issue 2
Abstract
There are few studies with up dosing of different 2nd generation antihistamines. This study evaluates efficacy and safety of high doses of Levocetirizine and Fexofenadine in chronic urticaria. This study includes 24 patients with chronic urticaria. Initially Fexofenadine 180 mg or Levocetirizine 5 mg was started. Doses of study drugs were doubled at the end of 1 week and tripled at the end of 2 weeks in non-responders and continued up to 4th week. Patients completed 2 week treatment with highest doses were included in the analysis. All patients were evaluated for symptoms, VAS for sedation and critical flicker fusion threshold (CFFT) for coordination before and after study. Reduction in mean total symptoms score and CFFT were highly significant in Fexofenadine group. Conclusion: Fexofenadine is superior to Levocetrizine in high doses in reducing mean symptoms score and sedation and no impairment in coordination in patients with chronic urticaria.
Authors and Affiliations
D. Aruna, M. Padmaja, S. P. Vijayalakshmi
Keywords
Related Articles
- EP ID EP505795
- DOI -
- Views 37
- Downloads 0
Reasons for discarding blood and blood components in a State of Art Model Blood Bank in a tertiary care teaching hospital
Blood transfusion is an integral part of medical practice. Human blood till date has no substitute. Proper utilization of whole blood and blood components is necessary so that there is minimal wastage. A total of 31655(v...
CLASSIFICATION AND POTENTIAL OF ADVERTISING ON SOCIAL NETWORKS
The advertising exertions in social networks is developing each year. Meanwhile their presence in the late 1990s Social Network Web Sites were measured as a uniform gathering. The main separation factors were the quantit...
SOCIOECONOMIC STATUS AMONG INFERTILE COUPLES
Introduction: Infertility is the common health problem in developing countries like India. Infertility has been associated with the various socioeconomic condition and anthropometric parameters. It is the matter of socia...
A SINGLE CASE STUDY ON VELOCARDIAL FACIAL SYNDROME(VCFS)
Velocardiofacial Syndrome(VCFS) is a genetic condition characterized by abnormal pharyngeal arch development. The general Characteristics of VCFS include cleft lip palate (CLP) usually of the soft palate, heart problems,...
COMPARISON OF DEXMEDETOMIDINE AS AN ADJUVANT TO ROPIVACAINE VS. ROPIVACAINE ALONE IN LOWER ABDOMINAL & LOWER LIMB SURGERIES; A RANDOMIZED CLINICAL TRIAL.
Background: Regional anaesthesia has a lot of advantages compared to general anesthesia such as effective motor & sensory blockade , prolonged postoperative analgesia , no airway manipulation etc. Adding adjuvant like De...