Evaluation of Efficacy of Platelet Rich Plasma as a Scaffold in Regenerative Endodontic Treatment: An in-vivo study
Journal Title: Journal of Advanced Medical and Dental Sciences Research - Year 2018, Vol 6, Issue 12
Abstract
Background: In the past years, there has been several discoveries regarding regenerative endodonticsStudies conducted in the past showed that platelet concentrates can be used as a scaffold for regeneration. These platelet concentrates can be easily prepared in dental environment, are autologous and are high in growth factors like transforming growth factor, platelet derived growth factor and endothelial growth factor.The present study was conducted with the aim to determine PRP as a scaffold in regenerative endodontics. Materials and methods: The study was conducted in the Department of dentistry at the institute. The study included immature single rooted teeth that required root canal treatment. Teeth were randomly divided into two groups- group I received PRP and Group II received blood clot. Triple antibiotic powder (metronidazole, cefalor, ciprofloxacin) was placed. Subjects were recalled after 3 weeks for the resolution of symptoms and the triple antibiotic powder was placed again.Vitality was assessed, and the radiographs were taken to determine apical closure and periapical healing. Radiographic root area was measured preoperatively and postoperatively by a trained radiologist who was blinded. All the data was arranged in a tabulated form and analysed statistically using SPSS software. Results: The mean age of the subjects was 10.24 years. There were 12 males (60%) and 8 females (40%) in the study. Mean first preoperative reading was 18.35+/-3.23. mean second preoperative reading was 18.30+/-3.21. There were 50% teeth in Group I and 20% teeth in Group II that showed positive response to vitality tests. Conclusion: Platelet rich plasma are a useful scaffold material for regenerative endodontics, it favorably lead to apical closure and positive vitality test
Authors and Affiliations
Parul Verma
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