Evaluation of efficacy of regimens containing zidovudine, stavudine and tinofovir
Journal Title: International Journal of Medical Research and Review - Year 2016, Vol 4, Issue 7
Abstract
Objective: Aim of the study, was to compare the efficacy of regimens containing zidovudine, stavudine and tinofovir by comparing CD4 counts of patients at the end of 2 years. We also aim to evaluate their efficacy, by comparing basal CD4 count and CD4 count at 2 years in patients on these three regimens. Methodology: A retrospective observational study was conducted on 128 HIV patients, receiving various antiretroviral regimens in a teaching hospital in coastal Karnataka. Data of patients who were diagnosed to be HIV positive, receiving HAART and were attending the hospital for regular follow up once in six months was collected in data extraction form. Regimens containing zidovudine, stavudine and tinofovir were evaluated by comparing 2 year CD4s of patients. Effectiveness of each regimen was evaluated by comparing basal CD4 count with CD4 count at the end of 2 years. Results: We did not find any significant difference in basal CD4 counts in 3 regimens. CD4 count at the end of 2 years differed significantly (P<0.05) between the groups. Stavudine receiving patients had significantly higher (P<0.05) CD4 count as compared to AZT treated patients. Patients treated with TDF had highly significant (P<0.0001) elevation in CD4 count compared to that of AZT. However d4T and TDF didn’t have significant difference in CD4 counts at the end of 2 years. Patients in each group had extremely significant elevation in CD4 counts (p=0.0000) as compared to basal levels. Conclusion: We can conclude that TDF containing regimen is more effective than that containing AZT or d4T, based on the CD4 count at the end of 2 years and the extent of elevation of CD4 count.
Authors and Affiliations
Sachidananda Adiga, BN Malawadi,, Usha Adiga
Keywords
Related Articles
- EP ID EP230597
- DOI 10.17511
- Views 118
- Downloads 0
A rare case report on colloidion baby syndrome with severe ectropion in neonates
Colloidion baby is a name given to baby born yellow, scaly wax like covering the baby. It is also known as lamellar icthyosis and is an inherited disorder present through birth. The disorder is a social stigma to the soc...
Elastosis in premalignant and malignant lesions of breast-A histopathological and histochemical study
Background: Stromal changes in all the premalignant, insitu/ microinvasive and invasive malignant lesions of breast helps in better understanding of disease process at the level of the tumor and host stromal reaction. Th...
Interrelation between birth weight, body mass index, insulin resistance, C-Reactive Protein-hs, adiponectin and leptin in children (Age 10 to 20 years)
Background: India is projected to have one of the largest populations of obese children over the next decade. Birth weight reflects maternal nutrition and fetal programming which may be a leading cause of obesity. Adipok...
Ultrasound evaluation of fetal central nervous system anomalies and its correlation with postnatal outcome
Introduction: CNS anomalies are the most serious congenital abnormalities. Ultrasound is an effective and non invasive modality of prenatal diagnosis of these anomalies. The purpose of the current study was to determine...
Comparison of CT only contour with MRI guided contouring in external beam radiotherapy for carcinoma rectum
Aim:The purpose of the study is to compare CT only contour with MRI guided contour for delineation of the gross tumour volume (GTV) in carcinoma of rectum in external beam radiotherapy.Materials and Methods:18patients wh...