Evaluation of efficacy, safety and cost effectiveness of oral iron and injectable iron sucrose and ferric carboxy maltose in pregnant women in 2nd and 3rd trimester in anaemia
Journal Title: Indian Journal of Obstetrics and Gynecology Research - Year 2017, Vol 4, Issue 1
Abstract
Objective: To compare the efficacy safety and cost effective of oral iron and injectable iron sucrose and FCM in pregnancy in 2nd and 3rd trimester. Methods: A prospective randomised control trial study in 300 women with HB 7-9gm% done in department of obstetrics on Gynae in Muzaffarnagar Medical College, Muzaffarnagar. Result: Mean changes in Hb: oral iron 9.14gm%, inj.iron sucrose 10.54gm%, inj FCM 11.66gm%. The value of p is < 0.00001. The result is significant at p ≤0.05. Mean changes in PCV: oral iron 25.1%, inj iron sucrose 36.7%, inj FCM 37.46%. The value of p is <0.00001. The result is significant at p ≤ 0.05.Mean changes in MCV: oral iron 74.5Fl. The value of p is 0.172115. The result is not significant at p ≤ 0.05., inj iron sucrose 72.52.4Fl, inj FCM 80.4Fl. The value of p is < 0.00001. The result is significant at p ≤ 0.05.Mean changes in MCHC: oral iron 32.9%, inj iron sucrose 37.6%, inj FCM39.31%. The value of p is < 0.00001. The result is significant at p ≤ 0.05 Mean changes in serum feritin oral iron 28.95 µg/l, inj iron sucrose 29.25 µg/l, inj FCM 47.3µg/l. The value of p is < 0.00001. The result is significant at p ≤ 0.05.Mean changes in serum iron oral iron 36.27µg/dL, inj iron sucrose 38.1 µg/dL, inj FCM 73.8 µg/dL. The value of p is < 0.00001. The result is significant at p ≤ 0.05. Mean decrease in TIBC: oral iron 369µg/dL, inj iron sucrose 330µg/dL, inj FCM 324 µg/dL. The value of p is < 0.00001. The result is significant at p ≤ 0.05. Regarding efficacy both oral iron and injectable group was statistically significant. The value of p is < 0.00001. The result is significant at p ≤ 0.05. Conclusion: We can conclude from this study that injection FCM is a promising alternative for IDA as its compliance is better than others, it can be safely used for correction of anaemia without any side effects over the mother and fetus.
Authors and Affiliations
Bharti Maheshwari, Varisha Mahtab, Smita Tyagi, Prachi Tyagi
Keywords
Related Articles
- EP ID EP313100
- DOI 10.18231/2394-2754.2017.0022
- Views 74
- Downloads 0
Ferric Carboxymaltose Injection in Postpartum Iron Deficiency Anemia: Results from the prescription-event monitoring study
Introduction: Ferric Carboxymaltose (FCM), a dextran free iron formulation can be administered in large doses without the risk of severe anaphylactic reactions in postpartum anemia (PPA). Evidence suggest that FCM is hig...
Evaluation of Umbilical Cord Coiling Index in late second trimester and its association with Perinatal Outcome
Background: Umbilical cord plays a major role for foetal persistence during the intrauterine period. Reports had shown that abnormal umbilical cord coiling in the form of hypo or hypercoiling are associated with abnormal...
Neurological disorders during pregnancy and puerperium-still a significant cause of maternal morbidity and mortality in Rural India
Introduction: A variety of neurological disorders may be encountered during pregnancy and puerperium. These disorders may be unrelated to the pregnant state (e.g., tuberculous meningitis) or peculiar to or more prevalent...
A study of post-surgical maternal mortality at tertiary care centre
Objective: To evaluate the post-surgical maternal deaths and to make recommendation & design a protocol for decreasing future mortality. Design Retrospective analysis of post-surgical maternal mortality. Methods Analysis...
Comparative study of oral versus vaginal misoprostol 25 mcg for induction of labour at term in a Medical College Hospital in South India – Prospective Study
Objective of the study is to compare the safety and efficacy of oral versus vaginal misoprostol 25mcg for induction of labour at term and to assess perinatal out come. Materials and Method: Study was conducted in the dep...