Evaluation of expression of p16INK4a & Survivin in squamous neoplasm of cervix- A 3 years study
Journal Title: Perspectives In Medical Research - Year 2017, Vol 5, Issue 1
Abstract
Background: To explore the expression of p16INK4a(p16) & survivin in cervical intraepithelial neoplasm (CIN) & cervical squamous neoplasm Material and Methods : A 3years study was undertaken in MGM Hospital, Warangal, all the cervical & hysterectomy specimens were studied. By considering both exclusion & inclusion criteria 46 cases were taken for p16INK4A & survivin expression & data was analysed Results :The p16INK4A & survivin expressions showed the presence of statistical significance in cervical cancer, CIN1, CINII, CINIII and a normal cervical tissue & the comparison also revealed statistical significance among group. P16INK4A showed increase intensity with grade ( CINI = 28.57%, CINII = 44.44%, CINIII = 70%, & SCC = 90%), whereas survivin expressions were positive for both nuclear as well as cytoplasm staining( CINI = 28.57%, CINII = 22.22%,CINIII = 40%, SCC = 75% ) . Moreover, p16INK4A protein was associated with CIN grade & in cervical cancer; survivin protein was also related with clinical stages, CIN grade; the p16INK4A & survivin expressions were positively correlated with cervical cancer, & associated with poor prognosis of cervical cancer. Conclusion :Briefly, p16INK4A & survivin expressions were positively correlated with the clinic-pathological & prognosis of cervical cancer.P16INK4A linearly correlates well with increasing grade of CIN & SCC, whereas as survivin does not shows linear correlation with increasing grades of CIN . But it was the useful marker for differentiating CIN & SCC, especially in diagnostically difficult cases.
Authors and Affiliations
S. Lokesh Rao Magar
Keywords
Related Articles
- EP ID EP301092
- DOI -
- Views 126
- Downloads 0
ST elevation Myocardial infarction in the young - A clinical and Angiographic profile
Introduction: An increasing number of young adults are presenting with ST elevated Myocardial Infarction(STEMI).With urbanization, emerging economy, and a growing middle class adopting western diet, the prevalence of ris...
Chronic Lymphocytic Leukemia Presenting as Recurrent Pulmonary Infections
A 57 years old male presented to the pulmonary OPD with cough with sputum, fever, and loss of apetite. He gave a history of frequent hospitalization for cough and fever thrice in the recent past within one month in a nea...
Evaluation of expression of p16INK4a & Survivin in squamous neoplasm of cervix- A 3 years study
Background: To explore the expression of p16INK4a(p16) & survivin in cervical intraepithelial neoplasm (CIN) & cervical squamous neoplasm Material and Methods : A 3years study was undertaken in MGM Hospital, Warangal,...
Steele Richardson Olszewski syndrome
Introduction:Progressive supra nuclear palsy (PSP) or Steele Richardson Olszewski syndrome is a neurodegenerative disease of middle and late age. The clinical features of PSP are similar to that of Parkinsons disease (PD...
Impact of oral administration of ethanol leaf extract of Piliostigma thonningii on fertility hormones of male Wistar rats
Introduction: The quest for the safe herbal remedy for the management of erectile dysfunction and their relationship with male sexual hormones prompted this research. Aims and Objectives: It is aimed at determining the...