EVALUATION OF FREE RADICAL SCAVENGING ABILITY AND ANTIRADICAL ACTIVITIES OF XIMENIA CAFFRA FRUIT EXTRACTS AT DIFFERENT RIPENING STAGES
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2019, Vol 11, Issue 1
Abstract
Objective: To evaluate the free radical scavenging ability and antiradical activities of Ximenia caffra fruit extracts in their different ripening stages. Methods: Using standard procedures, Ximenia caffra fruit extracts were determined for ferrous ions chelating ability, nitric oxide and hydroxyl radical scavenging ability. Antiradical activities were assessed using 1,1-diphenyl-2-picrylhydrazyl (DPPH) in which the fruit extracts were evaluated for the number of antiradical units (AU515), the number of antiradical units per 1 mg of extracts (EAU515) and the total number of antiradical units per 1g of raw fruits (TAU515). Results: The fruit extracts exhibited significant higher ferrous ion chelating and free radical scavenging capacity compared to synthetic antioxidants (standard). Fruit extracts in early ripening stage (ERS) exhibited stronger ion chelation, nitric oxide and hydroxyl radical scavenging ability with low effective fruit extract concentration required to reduce free radicals by 50% (EC50) that were 14, 25 and 30µg/ml respectively than the late ripening stage (LRS) extracts. The fruit extracts also showed high AU515, EAU515 and TAU515. The values of AU515 ranged from 0.93 to 0.95, while EAU515 from 78.30 to 79.34 and TAU515 ranged from 19762.46 to 23821.23 of the extracts in LRS and ERS respectively. Conclusion: Based on these observations Ximenia caffra is potentially beneficial to human health due to its strong ability to scavenge free radicals. Its utilization can potentially reduce the risk of degenerative diseases to human beings.
Authors and Affiliations
Pensia E. Mapunda, Cosmas Mligo, Herbert V. M. Lyaruu
Keywords
Related Articles
- EP ID EP566063
- DOI 10.22159/ijpps.2019v11i1.29065
- Views 85
- Downloads 0
ROLE OF GREEN TEA AND ITS CONSTITUENT EPIGALLOCATECHIN-3-GALLATE IN THE HEALTH MANAGEMENT
Green tea and its constituents is natural beverage used worldwide especially in Asian countries and also used as natural medicine for thousands of years. The current approaches for diseases treatment based on allopathic...
COMPARISON OF COMMERCIALLY AVAILABLE DRUGS FOR TYPE 2 DIABETES WITH NATURAL MOLECULE FROM TINOSPORA
Objective: Efficacy of natural molecule from Tinospora cordifolia versus commercially available drugs to control diabetes 2.Methods: Twelve different drug molecules were selected to study drug properties, bioactivity and...
ANTIOXIDANT ACTIVITIES OF SOME WILD EDIBLE PLANTS OF MEGHALAYA STATE IN INDIA AND EFFECT OF SOLVENT EXTRACTION SYSTEM
Objective: The antioxidant activities of some wild edible plants of different botanical families growing in the Meghalaya state, India e. g the bulb of Dioscorea bulbifera, the underground stem of Homalomena aromatica, f...
ASSESSMENT OF GESTATIONAL DIABETES MELLITUS RELATED STRESS USING A SPECIFIC SCALE ADMINISTERED AS AN ONLINE MOBILE APPLICATION
Objective: Aim of the study was to assess the Gestational Diabetes Mellitus (GDM) related stress among pregnant women using an online mobile application based specific stress scale for GDM. Methods: This was a prospecti...
DISSOLUTION BEHAVIOR OF CARBAMAZEPINE SUSPENSIONS USING THE USP DISSOLUTION APPARATUS 2 AND THE FLOW-THROUGH CELL METHOD WITH SIMULATED GI FLUIDS
Objective: To characterize the dissolution behaviour of carbamazepine generic suspensions using the USP Dissolution Apparatus 2 and the flow-through cell method with simulated gastrointestinal fluids as dissolution media...