Evaluation of Heamodynamic Responses upon Using Dexmedetomidine Infusion in Hypertensive Patients under General Anaesthesia
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 7
Abstract
Background: The objective of this study was to compare the effects of intravenous dexmedetomidine and saline placebo on intra operative haemodynamics in hypertensive patients. Methods: In a double blinded trial, forty hypertensive patients were randomly allocated to receive either dexmedetomidine 0.5 μg /kg/h (Group D) (n = 20) or saline placebo (Group N) (n = 20) intra-venously, started immediately after intubation. Heart rate (HR) and mean arterial pressures (MAPs) were recorded throughout. Results: Dexmedetomidine caused significant fall in MAP, 15 min after starting infusion (P<0.001). Also, patients in group D had fall in heart rate and MAP (P= 0.244) while in Group N showed mild increase in heart rate and a highly significant fluctuation in MAP (P<0.001). Conclusion: These findings suggest that an infusion of dexmedetomidine in hypertensive patients attenuates circulatory reflexes during surgery and at extubation, thus provided stable haemodynamics both intra operatively and at extubation.
Authors and Affiliations
Sheeba Franklin
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