EVALUATION OF HEMATINIC ACTIVITY OF NAGA BHASMA IN PHENYLHYDRAZINE-INDUCED ANEMIA IN EXPERIMENTAL RATS
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 2
Abstract
Objective: Bhasmas are biologically produced nanoparticles prescribed with several other medicines of Ayurveda. Metal-based drugs are prepared by transmutation of base metals into noble ones along with the use of plant extracts meant to eradicate the toxic effects of metal. Naga bhasma (NB) is one of such metallic preparation used in various diseases such as diarrhea, spleen enlargement, and diabetes. The present study aims to test the hematinic activity of NB against phenylhydrazine (PHZ)-induced anemia in rats. Methods: The experiment was carried on Wistar rats of either sex (150–200 g). Anemia was induced by an oral administration of PHZ 40 mg/kg for a period of 2 days. Hemoglobin (Hb) was measured on the 3rd day. Rats with Hb <11 g/dl were selected for the study. The animals were divided into six groups containing six animals each. Group I served as normal control, Group II as anemic control, and Group III was considered as standard that received ferrous sulfate (100 mg/kg), while Groups IV, V, and VI were treated with test NB 100, 200, and 400 mg/kg, respectively, for 15 days. Hb was checked on the 0, 2nd, 7th, and 15th days. Results: Oral administration of PHZ decreased Hb from 14 g/dl at day 0 to 11 g/dl at day 2. NB induced a significant increase in Hb concentration to 13 at the dose of 100 mg/kg p.o. after 48 h. Conclusion: PHZ decreased Hb rate inducing anemia. NB caused an increase in the Hb values in anemic rats. Thus, it can be concluded that NB exhibits significant hematinic activity in rats.
Authors and Affiliations
YADAV AV, UNDALE VR
Keywords
Related Articles
- EP ID EP608761
- DOI -
- Views 132
- Downloads 0
HIGHLY EFFICIENT SYNTHESIS OF 2,4-DISUBSTITUTED OXAZOLES THROUGH PALLADIUM/COPPER COMEDIATED DIRECT ARYLATION REACTION
Objective: The aim of the present study is to synthesize 2,4-disubstituted oxazoles through palladium/copper comediated direct arylation reaction.Methods: 2,4-disubstituted oxazoles (3a-i) have been synthesized by the re...
ANTIDIABETIC ACTIVITY OF KALANCHOE PINNATA IN ALLOXAN-INDUCED DIABETIC RATS
Objective: The main purpose of the present study was to analyze the antidiabetic activity of methanolic extract of the leaf of Kalanchoe pinnata in alloxan-induced diabetic rats. Methods: Diabetes mellitus (DM) is a chr...
BIOCHEMICAL SCREENING OF MARINE MICROMONOSPORA MARINA KPMS1 (MH036351) AND ITS ANTIBACTERIAL ACTIVITY AGAINST MULTIDRUG RESISTANT BACTERIA
Objective: The present investigation aimed at the screening of pharmaceutically potential antimicrobial metabolite isolated from marine Micromonospora sp. to combat the multidrug‑resistant bacteria. Materials and Method...
OXIDATIVE STRESS REDUCING AND LIVER PROTECTIVE EFFICACY OF ETHYL ACETATE FRACTION ISOLATED FROM PAJANELIA LONGIFOLIA (WILLD) K. SCHUMAN
Objectives: We investigated the liver protective as well as oxidative stress reducing activity of isolated fractions (Pajanelia fraction-1, 2, and 3 [PF1, PF2, and [PF3]) from ethyl acetate extract of Indian medicinal pl...
ANTIHYPERTENSIVE EFFECT OF RUTIN: PHARMACOLOGICAL AND COMPUTATIONAL APPROACH
Objective: Phenolic compounds, such as flavonoids, have aroused great scientific interest due to their diverse pharmacological activities. Several studies suggested that flavonoids act as antihypertensive by inhibiting a...