Evaluation of Hepatoprotective and Antioxidant activity of Euphorbia cyanthophora
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2013, Vol 2, Issue 3
Abstract
The present study was carried out to evaluate the hepatoprotective and antioxidant effect of the methonalic extract of Euphorbia cyathophora (MEEC) in Wistar albino rats. Protective action of MEEC was evaluated using animal model of hepatotoxicity induced by acetaminophen (2 g/kg, bw, p.o,). Liver maker enzymes were assayed in serum and antioxidant status was assessed in liver tissue. Histopathology was also studied. Levels of aspartate aminotransferase (AST), alanine aminotransferace (ALT), alkaline phosphatase (ALP) and total bilirubin were increased and the levels of total protein were decreased in acetaminophen treated rats. MEEC at (400 mg/kg, bw, p.o,) does decreased the elevated levels of all these biochemical parameters and restored the normalcy of total protein significantly. Lipid peroxidation (LPO) was increased significant in liver tissue in the acetaminophen treated rats while the activities of reduced glutathione (GSH), catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD) were decreased. MEEC at the doses of (400 mg/kg, b w, p. o,) decreased the elevated levels of lipid peroxide and restored the normalcy of GPX, GSH, CAT and SOD. Histopathology also shows similar result. Silymarin is used in standard for this study. From this study it can be concluded that the MEEC showed significant hepatoprotective and antioxidant action.
Authors and Affiliations
M. Chitra M. Chitra
Keywords
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