EVALUATION OF HEPATOPROTECTIVE AND ANTIOXIDANT EFFECT OF COMBRETUM ALBIDUM G. DON AGAINST CCl4 INDUCED HEPATOTOXICITY IN RATS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 9
Abstract
Objective: The present investigations were undertaken to evaluate the hepatoprotective and antioxidant activity of the ethanolic extract of the whole plant of Combretum albidum G Don against CCl4-induced hepatotoxicity in rats.Methods: Hepatoprotective effect of ethanolic extract of Combretum albidum (EECA) was determined by using carbon tetrachloride (CCl4) intoxication of rats as experimental models. The extent of liver damage and effect of the plant extract was assessed by various biochemical parameters like alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total billrubin (TB) and total protein (TP) in blood serum and concentration of thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-s-transferase (GST) in liver were determined. Histopathological changes in the liver of different groups were also studied.Results: The administration of EECA at dose levels of 250 and 500 mg/kg/b.w., orally had decreased the rise of ALT, AST, ALP, TB and TBRAS levels and the effects were comparable to standard drug (Silymarin 25 mg/kg/b. w,) the GSH, SOD, CAT, GPx, GST and TP levels were significantly increased in the animals received EECA. The histopathological studies show decreased necrosis and hepatocellular degeneration when compared to the CCl  intoxicated liver.Conclusion: This study demonstrates that the hepatoprotective and the antioxidant activity of the whole plant of Combretum albidum therefore scientifically supports the use of this plant in traditional medicine for treatment of liver disorders.
Authors and Affiliations
D. Rajalingam, R. Varadharajan, S. Palani
Keywords
Related Articles
- EP ID EP576038
- DOI 10.22159/ijpps.2016.v8i9.13136
- Views 50
- Downloads 0
PHARMACOGNOSTIC STANDARDISATION AND CHROMATOGRAPHIC FINGERPRINTING OF LEAVES AND FRUITS OF ZANTHOXYLUM RHETSA
Objective: To conduct pharmacognostic standardisation and chromatographic fingerprinting of leaves and fruits of Zanthoxylum rhetsa.Methods: The macroscopic, microscopic and physicochemical evaluation of the crude drugs...
ANTI-ULCER AND ANTIOXIDANT ACTIVITY OF NELUMBO NUCIFERA GAERTN STALKS IN RATS
Objective: Nelumbo nucifera Gaertn. (Nymphaeceae) is a well known aquatic herb which has been extensively used traditionally for the treatment of different diseases. Therefore present study was designed to evaluate the a...
TREATMENT OF TINEA VERSICOLOR CAUSED BY MALASSEZIA FURFUR WITH DILL SEED EXTRACT: AN EXPERIMENTAL STUDY
Objective: Pityriasis versicolor (PV) is a superficial fungal infection of the skin characterized by changes in skin pigment due to colonization of the stratum corneum by a dimorphic lipophilic fungus of the normal flora...
ENVIRONMENTALLY BENIGN SYNTHESIS OF N'-SUBSTITUTED NAPHTHALENE-1-SULFONOHYDRAZIDE UNDER MICROWAVE IRRADIATION AND THEIR BIOLOGICAL EVALUATION
Objective: Microwave synthesis provides an alternative environmentally benign method with excellent yield and shorter reaction time. The aim of this study is to synthesize some new sulfonohydrazide derivatives by convent...
USE OF CASHEW BARK EXUDATE GUM IN THE PREPARATION OF 4 % LIDOCAINE HCL TOPICAL GELS
Objective: The objective of the current work was to prepare and evaluate ex vivo skin permeation of cashew bark exudate gum based 4 % lidocaine HCl topical gels.Methods: In the current work, 4 % lidocaine HCl topical gel...