EVALUATION OF HOMOCYSTEINE AND FOLIC ACID LEVELS IN PREGNANCY LOSS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 25
Abstract
BACKGROUND Hyperhomocysteinaemia is associated with several pregnancy related complications such as recurrent pregnancy loss, preeclampsia and abruption. Folic acid, apart from being a part of the homocysteine metabolism, also has a foetus-protective role in pregnancy. The aim of this study was to assess the relationship of fasting total plasma homocysteine level and serum folic acid level with pregnancy loss. MATERIALS AND METHODS Participants were categorised into cases (Women with Pregnancy Loss) and controls (Normal Antenatal Women) with N= 100 each. Enzymatic photometric estimation of fasting total plasma homocysteine and folic acid levels was done. Data was statistically analysed. RESULTS The analysis by t-test showed that the mean fasting total plasma homocysteine level was statistically higher in cases (13.85 ± 12.04 μmol/L) as compared to controls (10.19 ± 2.57 μmol/L), p < 0.05. The mean folic acid level was significantly lower in patients with pregnancy loss (11.85 ± 5.13 ng/mL) as compared to controls (13.92 ± 3.73 ng/mL), p < 0.001. CONCLUSION The fasting total plasma homocysteine level was significantly higher and folic acid level was significantly lower in women with pregnancy loss. The difference was more in women who experienced pregnancy loss four times.
Authors and Affiliations
Premakuma E. , Sowganthika N. I. , Sowkanthika P.
Keywords
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- EP ID EP450623
- DOI 10.14260/jemds/2018/659
- Views 91
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