EVALUATION OF HYPERHOMOCYSTEINAEMIA AS A RISK FACTOR FOR ISCHAEMIC HEART DISEASE IN YOUNG POPULATION
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 43
Abstract
BACKGROUND Cardiovascular diseases are leading causes of mortality and morbidity in today’s world. Numerous studies have evaluated a spectrum of both modifiable and non-modifiable risk factors of CVD in the young population. Among them homocysteine is novel and plays a role in increasing oxidative stress, thrombogenicity and endothelial dysfunction. The purpose of the present study was to evaluate plasma homocysteine levels in young Goans ≤ 45 years of age, presenting with acute coronary syndrome and to assess the role of hyperhomocysteinaemia and its relationship with other conventional risk factors for coronary artery disease. MATERIALS AND METHODS Case and Control groups were studied for clinical characteristics and risk factors using health assessment questionnaire and lab investigations, which included homocysteine levels. Settings and Design- This was a retrospective, observational, case-control study conducted at Goa Medical College, Bambolim, a tertiary care institute, over a period of one year and included 60 young patients, ≤ 45 years of age of which 40 were cases presenting with acute coronary syndrome and 20 were similar controls without evidence of IHD according to the inclusion and exclusion criteria. RESULTS It was observed that mean serum Homocysteine level was 20.32 ± 1.36 µmol/L in the case group and 12.92 ± 0.63 µmol/L in the control group. By statistical analysis, it was deducted that a significant correlation exists between high serum homocysteine levels and the risk of developing premature coronary artery disease with odds ratio of 27.968 and highly significant p-value. High homocysteine levels were observed in majority of cases who were obese, hypertensive, diabetic or smokers and those with dyslipidaemias in comparison with controls. CONCLUSION The study concluded that hyperhomocysteinaemia is a risk factor for premature CAD in young Goan patients with acute coronary syndrome. The study also showed that smoking, dyslipidaemia, diabetes mellitus and hypertension are associated with hyperhomocysteinaemia.
Authors and Affiliations
Gauri Malhar Nilajkar, Anar Viraj Khandeparkar, Rukma Jagannath Kolwalkar
Keywords
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- EP ID EP548980
- DOI 10.14260/jemds/2018/1041
- Views 87
- Downloads 0
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