Evaluation of hypoglycemic effect of ethanolic seed extracts of Citrullus lanatus
Journal Title: The Journal of Phytopharmacology - Year 2013, Vol 2, Issue 6
Abstract
Background: Diabetes is one of the most serious, chronic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. It is becoming the third “killer” of the health of mankind after cancer and cardiovascular diseases. Diabetes is a metabolic disorder affecting about 220 million people worldwide. A number of plants have been described in Ayurveda for the management of diabetes. The present study was aimed to find out the hypoglycemic and non-toxic effect of Citrullus lanatus seed extracts. Materials and Methods: In acute toxicity study, there was no mortality observed up to the maximum dose level of 2000 mg/kg body weight of the extract after administered orally. After toxicity studies the various extracts of plant were used for hypoglycaemic activity in which the ethanolic extract showed very good reduction in blood glucose level. From that three doses were selected for oral glucose tolerance test and 400 mg/kg of ethanolic seed extract showed better glycaemic control. Hence antidiabetic studies were conducted with 400 mg/kg dose level for 30 days and the tissues antioxidant levels and histopathological studies were carried out by using standard protocols. Results: The ethanolic extract of Citrullus lanatus helps to maintain the antioxidant level in various organs and also helps to protect the organs from oxidative damage. Conclusion: From our study, the ethanolic seed extract of Citrullus lanatus controls the blood glucose level and also helps to prevent the organ from oxidative damage. Hence it can be used in the management of diabetes mellitus.
Authors and Affiliations
Sumam Varghese, R. Narmadha, D. Gomathi, M. Kalaiselvi, K. Devaki
Plants used in Bandjoun village (La'Djo) to cure infectious diseases: An ethnopharmacology survey and in-vitro TimeKill Assessment of some of them against Escherichia coli
An ethnopharmacology survey concerning the medicinal plants used in Bandjoun village (La'Djo) to cure infectious diseases was carried out in three districts of this village. The survey led to the identification of 79 m...
Potent Indian herbs used for the cure and management of Diabetes
Diabetes is a chronic disorder of carbohydrate, fat and protein metabolism characterized by increased fasting and post prandial blood sugar levels. The global prevalence of diabetes is estimated to increase, from 4% in...
Evaluation of abortifacient efficacy of Rumex steudelli (Tult) root traditionally used medicinal plant in South West Ethiopia
The practice of traditional medicine for the control of fertility in most part of South Western Ethiopia is based on the uses of plant medicine for many years. The present study was carried out in female albino rat to e...
Effects of Ganoderma lucidum (Curtis) P. Karst and Crinipellis schevczenkovi Buchalo aqueous extracts on skin wound healing
The aqueous extracts of Ganoderma lucidum 1900 (Curtis) P. Karst and Crinipellis schevczenkovi 31 Buchalo mycelia were investigated for skin wound healing activity in vivo using the excision wound healing model. The ex...
Withania somnifera attenuates nicotine induced locomotor sensitization and withdrawal symptoms in mice
Objective: To investigate the effect of withania somnifera extract (WSE) on nicotine mediated reinforcement effect and withdrawal symptoms which attributed for the addiction liabilities of nicotine. Methods: In Swiss a...