Evaluation of IL-6 levels in Patient with Chronic Generalized Periodontitis : A Case Control Study
Journal Title: Journal of Advanced Medical and Dental Sciences Research - Year 2018, Vol 6, Issue 10
Abstract
Background: Chronic periodontitis is an inflammatory disease affecting the supporting tissues of teeth. The expression of the disease results from the interaction of host defense mechanisms, microbial agents, environmental, and genetic factors.Aim of the study: To evaluate IL-6 level in patient with chronic generalised periodontitis. Materials and methods: The study was conducted in the Department of Periodontology of the medical institution. For the study, we selected 30 patients with chronic periodontitis and 30 control subjects. A sample of gingival was surgically removed from the patients for the estimation of IL-6 in the gingival tissue. The estimation of IL-6 for each patient was done using ELISA method following the manufacturer’s instructions. The level of IL-6 for each patient was noted and was subjected to statistical analysis. Results: A total of 30 patients were enrolled in each group, Chronic periodontitis group and Control group. The mean age of patients in periodontitis group was 34.56 years and in control group was 33.45 years. Mean IL-6 level in periodontitis group was 28.12 pg/mL and in control group was 15.92 pg/mL. Conclusion: From the results of present study, this can be concluded that patients with chronic generalized periodontitis tend to have elevated level of IL-6. These salivary biomarkers are likely to provide great clinical benefit when supplemented with other clinical information.
Authors and Affiliations
Rohi Rashid
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