EVALUATION OF IMMUNOMODULATION ACTIVITY OF SOMANATHI TAMRA BHASMA
Journal Title: Journal of Biological and Scientific Opinion - Year 2014, Vol 2, Issue 6
Abstract
Somanathi Tamra Bhasma is a special method of preparation of tamra bhasma by using shudha tamra, parada, gandhaka, haritala and manashila and which is considered as more effective and less toxic. Tamra possess properties like brimhana, pramehagna and hridya. Therefore it is expected to have immunomodulatory effect. Evaluation of Immunomodulation activity of somanthi tamra bhasma was carried out in S.D.M. Centre for Research in Ayurveda and Allied Science Udupi, Karnataka, India through animal experimentation. Effect of somanathi tamra bhasma on cell mediated Immunity were evaluated by using Immunological paw edema method in albino rats and effect of somanathi tamra bhasma on humoral antibody formation were evaluated by noting Antibody titer and Biochemical, Haematological, and Histopathological findings. Analysis of the results obtained from the Immunomodulation study, clearly shown that, the test drug somanathi tamra bhasma has CMI suppression effect. This effect is produced without affecting anti-body formation indicating specific nature of the observed effect. It is suggested that this effect may be due to modulation of the Th-1 pathway of adaptive immune reaction. Haematological parameter assessment did not reveal any remarkable change. Among the biochemical parameters elevation of SGOT was observed after SRBC injection and was moderately reversed by the test formulation. Thus it can be suggested that this formulation can be employed in clinical conditions involving inappropriate increase in CMI.
Authors and Affiliations
James Joseph, Sudheendra Honwad, Navinchandra N. H. , Ravi M. , Ravishankar B.
Keywords
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- EP ID EP142605
- DOI 10.7897/2321-6328.02689
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