EVALUATION OF IMMUNOMODULATORY ACTIVITY OF EXTRACT FROM RIND OF NEPHELIUM LAPPACEUM FRUIT
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2017, Vol 9, Issue 1
Abstract
Objective: Nephelium lappaceum Linn (Sapindaceae), also known as Rambutan is a tropical fruit native to Malaysia. The rind of Rambutan, which is normally discarded, has been used in the present research work to explore the immunomodulatory activity of ethanolic extract and also its protective effect against cyclophosphamide (CP) induced immunosuppression.Methods: The assessment of immunomodulatory activity was carried by testing the humoral (Haemagglutination antibody titre (HA) model), cell-mediated immunity (delayed type hypersensitivity reaction model), haematological parameters, carbon clearance assay (phagocytic index), organ index (spleen and thymus) and histopathological study of mice thymus.Results: Administration of the ethanolic extract significantly increased the antibody titre and DTH response in response to sheep red blood cells when compared to normal control and CP control group. There was a prominent increase in the WBC count, spleen index, thymus index and the phagocytic index in immune suppressed group treated with ethanolic extract of Nephelium lappaceum rind compared to the immune suppressed control group.Conclusion: The result suggests that the ethanolic extract has the potential to modulate the immune system as well has a protective effect against CP-induced immune suppression.
Authors and Affiliations
Priyanka Shrestha, Mukund Handral
Keywords
Related Articles
- EP ID EP575749
- DOI 10.22159/ijpps.2017v9i1.13038.
- Views 85
- Downloads 0
SOME MULTIFUNCTIONAL LIPID EXCIPIENTS AND THEIR PHARMACEUTICAL APPLICATIONS
This review is generally focussed on lipid-based excipients in solid oral formulations which increase its bioavailability. Several approaches have been used to deliver the drug efficiently in the body, and lipid excipien...
STROKE OUTCOMES IN NON-DIABETIC, DENOVO DIABETIC AND DIABETIC INDIAN PATIENTS MEASURED BY MODIFIED RANKIN SCALE: AN OBSERVATIONAL STUDY
Objective: Hyperglycemia is a known risk factor which adversely impacts the outcomes in stroke patients compared to patients with normal blood glucose levels. Patients suffering from an acute stroke who are previously no...
EFFECT OF HEAT AND FILTER STERILIZATION ON THE EFFICIENCY OF COLEUS AROMATICUS AS AN ANTIBACTERIAL AGENT AGAINST DIABETIC WOUND PATHOGENS
Objective: The purpose of the present study is to evaluate the effect of sterilization on the efficiency of Coleus aromaticus on eradicating diabetic wound pathogens. Methods: The investigation was explored by deploying...
ISOLATION AND QUANTIFICATION OF TANNINS FROM THE ROOT BARK OF CLERODENDRUM INFORTUNATUM LINN. AND ASSESSMENT OF THEIR ANTIOXIDANT POTENTIAL AND ANTIPROLIFERATIVE EFFECT ON HCT-15 CELLS
Objectives: Clerodendrum infortunatum is a traditional Indian medicinal plant which has been used for the treatment of many diseases. The root bark juice is effective against indigestion and abdominal pain. Based on the...
NIMESULIDE: DISSOLUTION PROFILE, VALIDATION OF ANALYTICAL METHODS FOR CAPSULES, AND ASSESSMENT OF PRODUCT QUALITY
Objective: The main objective of this paper was to evaluate the quality of similar (S, n=3) and generic (G, n=3) tablets and compounding capsules (C, n=6) containing nimesulide (100 mg).Methods: The parameters investigat...