EVALUATION OF IN VITRO ANTI-OXIDANT AND ANTI-ARTHRITIC ACTIVITY OF METHANOLIC EXTRACT OF MARINE GREEN ALGAE CAULERPA RACEMOSA
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 7
Abstract
Objective: The present study was aimed to evaluate in vitro anti-oxidant activity and in vitro anti arthritic activity of methanolic extract of Caulerpa racemosa.Methods: The in vitro anti oxidant activity was evaluated by using following method viz; DPPH scavenging activity, Nitric oxide scavenging activity, Total anti-oxidant activity, Determination of reducing power. The in vitro anti arthritic activity was evaluated by using protein denaturation method.Results: Methanolic extract of Caulerpa racemosa showed a very good anti-radical activity in scavenging DPPH radical and nitric oxide radical with maximum % inhibition of 88.87±1.05% at 2000μg/0.1 ml concentration and 80.49±1.43% at 2000μg/ml respectively. Total anti-oxidant activity and reducing power of Caulerpa racemosa was found to be 32μg equivalents of ascorbic acid at 500 μg/ml and 88.80±0.98% at 2000μg/0.05 ml respectively. The methanolic extract showed 49.33±0.597% of percentage inhibition at 1000μg/0.05 ml by protein denaturation method.Conclusion: From the results obtained, it can be concluded that the methanolic extract of Caulerpa racemosa possesses significant anti-oxidant and anti-arthritic activity. Further studies are required to signify the mechanism of action of these pharmacological activities and to mark them out for their significant pharmacological actions.Â
Authors and Affiliations
Sumanya H, Lavanya R, Umamaheswara Reddy C
Keywords
Related Articles
- EP ID EP578579
- DOI -
- Views 71
- Downloads 0
ASSESSMENT EFFECT OF ALOE VERA, AZADIRACHTA INDICA AND MORINGA OLEIFERA AQUEOUS EXTRACTS ON CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY IN RATS
Objective: This experiment aims to investigate the hepatotherapeutic effect of Aloe vera (AV), Azadirachta indica (N), and Moringa oleifera (MO).Methods: Eighty albino rats have been divided into ten groups. The first gr...
SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF INDOLE DERIVATIVES BEARING BENZIMIDAZOLE/BENZOTHIAZOLE MOIETY
Objective: The present work deals with the synthesis and characterization of biologically active new indole derivatives viz., 2-((1H-benzo[d]imidazol-2-yl)thio)-N-(4-(3-(1H-indol-3-yl)acryloyl)phenyl)acetamide 6a-d, N-(4...
A COMPARATIVE STUDY OF CHEMICAL COMPOSITION OF ACACIA SEYAL STEM, STEM WOOD AND STEM BARK DRY DISTILLATES USED BY SUDANESES WOMEN AS COSMETIC AND MEDICINE
Objective: The content and chemical composition of dry distillates of the stem, stem wood and stem bark of Acacia seyal were investigated. The distillates are fumigants of A. seyal locally known in Sudan as Dokhan and wi...
THE PATENTED DRUGS UTILIZATION: A STUDY AT NGUYEN DINH CHIEU HOSPITAL IN BEN TRE PROVINCE FROM 2011 TO 2017
Objective: With their new and efficacious active ingredients, patented drugs have important roles in offering high-quality healthcare. However, huge cost-related barriers in accessing patented drugs along with the availa...
ANTIOXIDANT AND ANTIPROLIFERATIVE POTENTIALS OF MARINE ACTINOMYCETES
Objective: The aim of present studyis to isolate and characterize a novel actinomycetes strain from marine sediments collected at Kakinada coast. To evaluate antioxidant and antiproliferative activities of the crude meth...