Evaluation of In Vitro Antidiabetic Activity of Synthesized Acetohydrazide Compounds
Journal Title: IOSR Journal of Applied Chemistry (IOSR-JAC) - Year 2018, Vol 11, Issue 1
Abstract
The aim of the current work is to screen in vitro inhibition of alpha-amylase enzyme activity in S1 ((E) – 2 – cyano – N’- (3-methyl-2,6-diphenylpiperdine-4-ylidene) acetohydrazide), S2 ((E) – 2-cyano-N’-(3- methyl-2,6, di-p-tolypiperidin – 4-ylidene) acetohydrazide) and S3 ((E) – 2-cyano-N’-(3-methyl-2,6, di-otolypiperidin – 4-ylidene) acetohydrazide). This in vitro study explores the antidiabetic properties of S1, S2 and S3 and it can be considered as a potential candidate for the management of type-II diabetes mellitus. The present findings exhibited a concentration dependent inhibition of α-amylase activity by S1, S2 and S3. The half inhibition concentration (IC50) of S1, S2, S3 and Acarbose tested against α-amylase were 1.240 0.648 0.2730.274mg/ml-1 respectively. The results of the study revealed that the antidiabetic activity of the S3 is much higher than that of S1 and S2 and near to the standard.
Authors and Affiliations
K. Sundaresan, Dr. K. Tharini
Keywords
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- EP ID EP413938
- DOI 10.9790/5736-1101011921.
- Views 185
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