Evaluation of In vivo antioxidant activity of a triterpene isolated from Madhuca Longifolia L leaves
Journal Title: IOSR Journal of Biotechnology and Biochemistry (IOSR-JBB - Year 2018, Vol 4, Issue 4
Abstract
Free radical stress leads to tissue injury and progression of disease conditions such as arthritis, hemorrhagic shock, atherosclerosis, diabetes, hepatic injury, aging and ischemia, reperfusion injury of many tissues, gastritis, tumor promotion, neurodegenerative diseases and carcinogenesis. Safer antioxidants suitable for long term use are needed to prevent or stop the progression of free radical mediated disorders. Many plants possess antioxidant ingredients that provide efficacy by additive or synergistic activities. Madhuca longifolia L leaves are used as strong astringent, used for the treatment of liver and spleen diseases, rheumatism and tumors. Antioxidant activity of the crude extracts of leaves of Madhuca longifolia L were assessed using reducing power assay, super oxide radical scavenging activity and hydroxyl radical scavenging activity. The potent fraction was tested for in vivo efficacy. Methanolic extract and isolated triterpene (derivative of Madhucic acid) exhibited potent antioxidant activity compared to the standard. In vivo studies on potent fraction demonstrated a reduction in hepatic malondialdehyde with simultaneous improvement in hepatic glutathione and LPO levels respectively, because of its natural origin and potent free-radical scavenging ability Madhuca longifolia L leaves can be used as a potential preventive intervention for free radical-mediated diseases.
Authors and Affiliations
Triveni S. Inganakal, Megha . T
Keywords
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- EP ID EP415122
- DOI 10.9790/264X-0404013135.
- Views 137
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