Evaluation of latex agglutination test (LAT) and efficacy in diagnosis of pyogenic meningitis in children
Journal Title: International Journal of Medical and Health Research - Year 2019, Vol 5, Issue 3
Abstract
Pyogenic meningitis is one of the most common and devastating disease of Central Nervous System, especially in children. We carried out an observational study with the aim was Evaluation of Latex Agglutination Test Efficacy in Diagnosis of Pyogenic Meningitis in children under 5 years during December 2012 to May 2013 in Paediatrics department of Dhaka Shishu (Children) Hospital, Dhaka, Bangladesh. We took our participants who were clinically suspected cases of pyogenic meningitis in children below 5 years of age admitted in our selected hospital. All the data were collected and recorded systematically in a questionnaire and entered into computer software SPSS (Statistical package for social sciences) version 20.0 edited and analyzed. Sensitivity and specificity of Gram stain, CSF latex were calculated. CSF cell count, Gram stain, Culture, LAT and Blood culture were the main outcome variables. A total of 100 cases of suspected meningitis in the age group below 5 years selected the study population. Majority of the patients belonged to ≤12 months. The most common clinical presentation was fever (100.0%) with median duration of 2 days. Ninety six (96) patients had convulsion and the median duration of continuation of convulsion was 1 day. Thirty eight patients had vomiting and median duration of continuation of vomiting was 1 day. A total of 100 clinically suspected cases of acute bacterial meningitis, laboratory confirmed cases were 36(36.0%), out of which 14(38.9%) cases were CSF culture positive, 10(27.8%) were Gram stain positive and 36(36.0%) were Latex agglutination test positive. Most frequently isolated organism were Streptococcus Pneumoniae 34(94.4%). The validity of test of serology (LAT) sensitivity was 100.0% and specificity was 74.4%, Gram stain sensitivity was 71.4% and specificity 100.0%. CSF culture is the ‘Gold standard’ and positive in 38.9% cases, but Latex agglutination test was 100.0% sensitive for detection of Antigen in CSF. In the conclusion, we can say. LAT can be a valuable tool in early diagnosis of acute pyogenic meningitis cases even after administration of antibiotics.
Authors and Affiliations
Dr. Kisoar Farhana Keya, ASM Nawshad Uddin Ahmed, Dr. Amal Kanti banik
Keywords
Related Articles
- EP ID EP583281
- DOI -
- Views 159
- Downloads 0
Acute calcific tendinitis of the wrist causing ulnar compressive neuropathy: A case report
e report a case of a 49 years old female, who presented to the emergency department with complaints of pain and swelling over the right wrist since 2 days. On examination, the swelling was tense, tender and there were re...
Patient satisfaction in king Abdulaziz medical city (KAMC)-Jeddah
Objective: To assess the level of patient’s satisfaction in different aspects of health care service in King Abdulaziz Medical City-Jeddah. Study Design: Cross sectional study. Data Collection Methods: Face to face inter...
Knowledge and practice of primary healthcare physicians for management of acne vulgaris in Sudair area, Saudi Arabia, 2017-2018
Acne is a common skin condition that affects different areas in body including face and neck. Acne vulgaris is very prevalent among teenagers and it affects also adults but in lower percent. Acne is treatable condition,...
Assessment of cases undergoing pancreatic surgery by ERAS (Enhanced recovery after surgery) protocol
Enhanced recovery after surgery (ERAS) is a multidisciplinary and evidence-based framework, developed to decrease perioperative surgical stress, accelerate postoperative recovery and significantly reduce the postoperativ...
Prevalence of depression in patients with hypertension
Introduction: Hypertension and depression are among the group of the most common chronic diseases worldwide, and according to numerous studies they are oftentimes associated. Objective and endpoint: To examine the preval...