Evaluation of Leptin Levels in Gingival Crevicular Fluid during Orthodontic Tooth Movement.
Journal Title: International Journal of Dental Science and Innovative Research (IJDSIR) - Year 2019, Vol 2, Issue 2
Abstract
Objectives: To test if leptin can be detected in the gingival crevicular fluid (GCF) and to determine whether any changes occur during orthodontic tooth movement. Materials and Methods: Thirty patients were included in the study in which canine retraction was carried out with a NiTi closed coil spring on either side. GCF samples were collected before the commencement of canine retraction, on the first, Six hrs and 21st day after application of force and were analysed for leptin levels by the ELISA technique. An upper canine requiring distal movement served as the test tooth; thecontralateral canine was used as a control tooth. The control tooth was included in the orthodonticappliance,but was not subjected to the retractive orthodontic force. GCF sampling from the distal sites of the test and control teeth was done at baseline, 1 hour, 6hours, and 21st day. Results: Leptin concentrations of the test teeth decreased in a time-dependent manner. When Compared with the baseline measurement, the decrease was stastically significant at 6hrs and 21st day (P <.001)but didn’t reach baseline value explaining inflammatory reactions immediately after forces applied . Conclusions: The concentration of leptin in GCF is decreased by orthodontic tooth movement; the results of the present study also suggest that leptin may have been one of the mediators responsible for orthodontic tooth movement.
Authors and Affiliations
Dr. Seema Pendharkar
Keywords
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