EVALUATION OF LIVER FUNCTION MARKERS AMONG WORKERS IN JEWELLERY UNITS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 10
Abstract
Objectives: Jewellery making unit workers are exposed to potent toxic chemicals and heavy metals during the manufacturing process. Various alloys are used during the manufacturing process of gold in which silver is used in higher concentration. The induction of metallothioneins (MTs) might occur due to the occupational exposure to heavy metals. Hence, the relationship of silver or MTs with liver function markers were investigated.Methods: A cross sectional study was conducted in the jewellery making units located in Coimbatore, Tamilnadu. A total of 211 participants [exposed (n = 158) and control (n = 53)] were included for the study and their liver function markers namely alanine amino transferase (ALT), aspartate amino transferase (AST), alkaline phosphatase (ALP), total protein, albumin, total/direct bilirubin and total cholesterol were estimated. Levels of serum silver and MTs were also assessed.Results: There were significant (p<0.05) increases of serum silver, MTs, ALT, AST, total cholesterol, total/direct bilirubin and significant (p<0.05) decrease of ALP, total protein and albumin in exposed groups compared to control group. Levels of MTs were positively correlated with ALT, AST, total cholesterol, total/direct bilirubin and were negatively correlated with albumin, total protein and ALP.Conclusion: The significant changes of liver function enzymes were observed due to the prolonged period of exposure to silver. However releases of these markers were in the normal range which might be due to the induction of MTs. The elevated levels of MT in the serum compared to control group pointed out that it might provide a cellular defense strategy against silver.Â
Authors and Affiliations
Shalini K. V, Jeyanthi G. P
Keywords
Related Articles
- EP ID EP579471
- DOI -
- Views 66
- Downloads 0
INHIBITION OF UREASE ENZYME ACTIVITY BY UREA AND THIOUREA DERIVATIVES OF DIPEPTIDES CONJUGATED 2, 3-DICHLOROPHENYL PIPERAZINE
Objective: Studies on enzyme inhibition remain an important area of pharmaceutical research since these studies have led to the discoveries of drugs used in a variety of physiological conditions. In search of novel ureas...
IN VITRO ANTHELMINTIC EFFICACY OF ALPINIA NIGRA AND ITS BIOACTIVE COMPOUND, ASTRAGALIN AGAINST FASCIOLOPSIS BUSKI
Objective: Alpinia nigra (Zingiberaceae) is a traditionally used medicinal plant of North-east India against helminthiases. In view of its medicinal property the present study was designed to see the anthelmintic propert...
ENANTIOMERIC SEPARATION OF ETODOLAC IN A BULK DRUG SUBSTANCE BY REVERSE-PHASE CHIRAL LIQUID CHROMATOGRAPHY METHOD
Objective: To develop novel, simple and rapid enantiomeric separation of Etodolac by reverse-phase high-performance liquid chromatographic method as per ICH guidelines.Methods: The R-isomer and S-isomer were baseline res...
EXTRACTION OF A WATER SOLUBLE BIOACTIVE HYPOXOSIDE AND ITS DEVELOPMENT INTO AN ETHOSOMAL SYSTEM FOR DEEP DERMAL DELIVERY
Objective: This study was aimed to extract Hypoxoside, a water soluble phytochemical, from the corms of Hypoxis hemerocallidea, and incorporate it into a suitable transdermal carrier system to increase its penetrability...
SCREENING OF ANTIOXIDANT ACTIVITY AND TOTAL PHENOLIC CONTENT IN RAPHANUS SATIVUS POD
Objective: The aim of this study was to evaluate the antioxidant activity and total phenolic content of Raphanus sativus L. Var. caudatus Alef pod extracts.Methods: In this study, the extract of R. sativus pod was prepar...