Evaluation of microbial and physico-chemical qualities of some cough syrups marketed in Sana’a city, Yemen
Journal Title: Journal of Pharmacy & Pharmacognosy Research - Year 2015, Vol 3, Issue 4
Abstract
Context: Microbial contamination of cough syrups can bring clinical hazards to the users or patients as well as physical and chemical changes in the product. Aims: To evaluate the microbial and physicochemical characteristics of two hundred samples of four different types of cough syrups marketed in Sana’a city, Yemen. Methods: All collected samples were subjected to the following examinations: the total microbial count, type of isolated microorganisms, physical parameters, and concentration of active ingredients were identified and assessed by standard techniques described in US Pharmacopeia. Results: All the cough syrup samples used contained viable microbial load within acceptable limit according Pharmacopeia specifications. Bacillus subtilis, Micrococcus fulvum, and Staphylococcus epidermidis were the most commonly recovered bacteria. However, Aspergillus niger, Aspergillus fumigatus, Penicillium notatum, Mucor sp., and Aspergillus flavus were the most fungi isolated. The physical properties represented in the appearance, density, and pH of the analyzed samples complied with Pharmacopoeia standards. The concentrations of diphenhydramine HCl (92,51 – 108,78%), pseudoephedrine HCl (94,55 – 109,07%), and triprolidine HCl (98,20 – 104,19%) were recorded. Conclusions: All cough syrups marketed in Sana’a City had good microbiological and physico-chemical qualities.
Physicochemical and chromatographic method of characterization of Matricaria recutita tinctures
Context: The pharmacological activity of medicinal products containing plant materials depends on their specific components. However, these components are not characterized in their entirety in all cases. Therefore, manu...
Sensorial, physical and chemical evaluation of bio-fortified Ipomoea batatas
Context: Bio-fortified sweet potato, Ipomoea batatas (L.) Lamarck beta-carotene rich, has been included in the most vulnerable population’s diet with the purpose of reducing health disturbances associated with hipovitami...
2,3-Butanedione monoxime attenuates the β-adrenergic response of the L-type Ca2+ current in rat ventricular cardiomyocytes
Context: 2,3-Butanedione monoxime (BDM), an uncoupler of cardiac contraction, is commonly used in enzymatic dissociations to prevent hypercontraction of cardiomyocytes and in cardioplegic solutions to decrease oxygen dem...
Evaluation of microbial and physico-chemical qualities of some cough syrups marketed in Sana’a city, Yemen
Context: Microbial contamination of cough syrups can bring clinical hazards to the users or patients as well as physical and chemical changes in the product. Aims: To evaluate the microbial and physicochemical character...
Limits determination of microbial contamination present on surfaces from a pharmaceutical microbiology district reference laboratory
Context: The bioburden present on the pharmaceutical microbiology laboratory’s surfaces, may increase the risk of cross-contamination when analytical tests are being carried out; periodic monitoring allows to set limits...