EVALUATION OF MUCUNA PRURIENS SEED EXTRACT FOR ITS ACUTE ORAL TOXICITY IN ALBINO RATS
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 2
Abstract
Objectives: The present study was carried out to evaluate the hydroalcoholic extract of Mucuna pruriens (HAMP) seeds for its acute oral toxicity in albino rats. Methods: Acute oral toxicity of MP seed extract was assessed in albino rats with three different doses of the extract with 175, 550, and 2000 mg/ kg body weight. Body weight, mortality, and clinical signs were recorded on 0 (before administration), 7th, and 14th days. Rats were sacrificed after day 14 and observed for any histological changes in the brain, heart, liver, and kidney tissues. Rats were normal up to 1 h and exhibited dullness and piloerection after 1 h which continued up to 2–4 h of observation period on day 0 of administration. All animals appeared normal from day 1 to throughout the experimental procedure. Results: No significant changes in the histological structure of the liver, kidney, and heart were noticed except mild congestion and hydropic changes only in liver tissue seen for 2000 mg/kg body weight of HAMP seeds. The seed extract of MP is non-toxic to rats and did not show any mortality nor the behavioral changes. In addition, it showed an increase in the body weight with the administration up to 2000 mg/kg body weight. Conclusion: MP seed extract signified as neurosuppressant, and the drug can be used in the treatment of neurological disorders characterized by hyperactivity of the neurons. The present data could provide adequate confirmation of the safety of MP for further experimental studies on a standardized formulation of the seeds extract.
Authors and Affiliations
GANGADHARA SWAMY, SURESH R RAO, RAJENDRA HOLLA
Keywords
Related Articles
- EP ID EP608804
- DOI -
- Views 147
- Downloads 0
“COSMECEUTICALSâ€: AN OPINION IN THE DIRECTION OF PHARMACEUTICALS
 Cosmeceuticals are the latest addition to the health industry and are described as cosmetic products with drug-like activities. Cosmetics are productsthat are used to cleanse and beautify the skin (Millikan, 2001). Pha...
QUALITY CONTROL EVALUATION OF IN HOUSE PREPARED POLYHERBAL AYURVEDIC FORMULATION SAPTAVIMSATIKA GUGGLU
Introduction: Plants and their constituent are having potential of treating any human suffering in form of disease. Various combination of plant extract is used as a remedy for treating these disorders. However the usage...
A COMPARATIVE STUDY OF EFFICACY AND SAFETY AMONG METFORMIN WITH SITAGLIPTIN, METFORMIN WITH VOGLIBOSE, AND METFORMIN WITH GLIMEPIRIDE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
Objective: Type 2 diabetes mellitus (DM) is a most common metabolic disorder. The present study aimed to compare the efficacy and safety among metformin with sitagliptin, metformin with voglibose, and metformin with glim...
AN EXPERIMENTAL STUDY EVALUATING THE INFLUENCE OF QUERCETIN ON MONOSODIUM GLUTAMATE-INDUCED DEPRESSION IN SWISS ALBINO MALE MICE
Objective: The objective of the study was to evaluate the antidepressant activity of quercetin in monosodium glutamate (MSG) model of depressed male mice. Methods: MSG was administered (500 mg/kg) to different groups of...
ACACIA SENEGAL BARK EXTRACT IN REGULATION OF HYPOTHYROIDISM: AN EXPERIMENTAL APPROACH
Objective: The objective of the present study was to evaluate the thyroid hormone stimulating efficacy of Acacia senegal (Gum Arabic) bark extract in 6-n-propyl-2-thiouracil (PTU)-induced hypothyroid albino rats.Methods:...