Evaluation of Myofibroblasts in Oral Squamous Carcinoma: An Immunohistochemical Study
Journal Title: Journal of Advanced Medical and Dental Sciences Research - Year 2017, Vol 5, Issue 12
Abstract
Background: The presence of cancer is followed by some changes that happen in epithelium & the normal stroma and normal stroma becomes a reactive one. Myofibroblasts secret cytokines and matrix metalloproteases which in turn contribute to the destruction of extracellular matrix and cause tumor growth. Hence; we planned the present study to assess the expression of myofibroblasts in oral squamous cell carcinoma (OSCC) cases. Methods: The present study included immunohistochemical assessment of expression of alpha smooth muscle actin (α-SMA) in OSCC cases. A total of 10 OSCC cases and 10 normal control were included in the present study. N Immunohistochemical staining of all the OSCC sections and normal controls (NC) was done. Immunostaining was assessed by the evaluation of the staining intensity and percentage of α-SMA-positive cells. Staining index for each group was calculated and compared. All the results were analyzed by SPSS software. Results: Staining index of myofibroblasts was positive in all the sections of OSCC and was significantly higher (p - value <0.05) as compared to normal control group. Conclusions: Myofibroblasts do play a significant role in epithelial malignant transformation.
Authors and Affiliations
Mohammad Shafi Dar, Ahmad Danish Rehan, Jiji George
Keywords
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