Evaluation of neuro-protective activity of Brihatvata Chinthamani Rasa
Journal Title: The Journal of Phytopharmacology - Year 2015, Vol 4, Issue 4
Abstract
The objective of the study was to screen the neuroprotective role of Brihatvata Chinthamani Rasa, a compound mineral formulation extensively used in stroke condition in the Indian system of medicine. The selected animals were grouped into four different categories and administered with group specific drugs for seven consecutive days. On seventh day an hour after drug administration all the rats were anesthetised. A midline incision was made and soft tissues were pulled apart and both bilateral common carotid arteries were exposed. The cerebral ischemia were induced by simultaneous occlusion of both common carotid artery for 30min, followed by acute ischemic reperfusion injury was produced by untying the temporary ligature and releasing the thread. At the end of the experiment, under anaesthesia animals were sacrificed and brain has been removed. Anti oxidant and histopathological investigation were carried out of brain tissue. Control group rats have shown increased lipid peroxidation and decreased levels of catalase and glutathione peroxidase activity, while the test drug administration significantly elevated catalase and considerable decrease in the lipid peroxidation in comparison to control group. Histopathological examination revealed there is a decreased cellularity and predominance of immature neurons in the granular layer was observed in hypothalamus in control rats while the test drug has shown normal cytoarchitecture. In conclusion the test drug possesses storing anti oxidant and retained normal cellular integrity of different brain regions.
Authors and Affiliations
Vikram Goshan, Ravi Mundugaru, Narayana Prakash, Sudhakar Bhat, Ravishankar Basavaiah
Keywords
Related Articles
- EP ID EP49640
- DOI -
- Views 228
- Downloads 0
Consequence of concurrent use of chloroquine and hydroalcoholic extract of Balanites aegyptiaca and leaf leatx of Aloe camperi
Prescription and/or over the counter medications when taken together with certain foods or herbal substances, leads to either increase or decrease a drug’s therapeutic out comes or adverse effects. It has been reported...
Evaluation of phytochemical, antioxidant and cytotoxic potential of Sesbania grandiflora Linn.
Sesbania grandiflora Linn. is perennial branching, small erect quick-growing short-lived soft-wooded tree, mostly cultivated in southeast Asian countries including India and grows primarily in hot, humid environments....
Antipyretic effect of a polyherbal ayurvedic formulation: A randomized controlled clinical study
The ancient ayurvedic text Aṣṭāṅgahṛdaya of Vāgbhaṭa (7th Century A.D.) prescribes a specific formulation of four plants having antipyretic properties with minimal side-effects. This polyherbal ayurvedic formulation co...
An overview of Ayurvedic & contemporary approaches to Psychodermatology
Aim & objective: The main objective of this paper is to increase the awareness of the psychodermal effect of different type of skin diseases with special reference to Psoriasis, Atopic dermatitis and Acne. Basis of evi...
A cross sectional study of knowledge, attitude and practices of menstrual hygiene among medical students in north India
Menstruation and menstrual practices are associated with taboos and socio-cultural restrictions. Good hygienic practices such as the use of sanitary pads and adequate washing of genital area are essential during menstr...