Evaluation of Neuroprotective Activity of Bauhinia Variegata on Haloperidol Induced Catalepsy in Rats
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 9
Abstract
An acetone soluble leaf extract from Bauhinia variegata was investigated for its neuroprotective effects in the haloperidol induced catalepsy rat model of the disease by measuring behavioural and biochemical parameters in the model. In rat model catalepsy was induced by administration of haloperidol (1 mg/kg, p.o) in wistar rats of either sex. A significant reduction in the catalepsy was observed in the drug treated groups when compared to the disease induced group. The biochemical parameters were Lipid peroxidation, Glutathione (GSH) , Glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were assessed in brain. Administration of haloperidol resulted in increased lipid peroxidation and decreased levels of antioxidant enzymes i.e GSH,GSH-Px and SOD. The study showed that the plant extract significantly decreased lipid peroxidation levels and increased antioxidant enzyme levels.
Authors and Affiliations
Vishakha Rajesh Trivedi
Keywords
Related Articles
- EP ID EP212441
- DOI -
- Views 35
- Downloads 0
Neonatal Liver Biopsy- Experience from a Tertiary Care Centre
Objectives: To clinch the diagnosis of complex neonatal liver diseases (where all other diagnostic modalities fail) this study was conducted in a Tertiary Care Centre of Northern India. Materials and Methods: The neonate...
Colon Surgery with & without Mechanical Bowel Preparation: A Comparative Study
Mechanical bowel cleansing is part of routine preoperative preparation of patients planned for colectomy worldwide. The commonly used bowel preparation agent is polyethylene glycol, but this drug causes severe morbidity....
Comparison of Two-Dimensional and Three-Dimensional Ultrasound Mammography to Characterize Benign and Malignant Breast Masses
The increased quality of images obtained with ultrasound has allowed investigators to define the characteristics of specific breast masses. Although various Classifications are in use ,most investigators agree to charact...
Nanoparticles in Irrigation and Disinfection of the Root Canal System – A Review
This article discusses use of nanoparticles in disinfection of the root canal system. the various nanoparticles discussed here are chitosan, silver, zinc oxide, bioactive glass and polylacticoglycolic acid nanoparticles....
Antibiotics Resistance among Major Foodborne Bacterial Pathogens
Bacteria-mediated food poisoning is a major contributing factor for the increase in a total number of hospital visits, stays, and emergency room (ER) visits among otherwise healthy people. In most cases, bacterial food p...