Evaluation of Nosocomial Infections after ABO-Compatible and Incompatible Liver Transplantations
Journal Title: Mediterranean Journal of Infection, Microbes and Antimicrobials - Year 2018, Vol 7, Issue 1
Abstract
Introduction: Liver transplantation is currently the only treatment option in acute hepatic failure and end-stage liver disease. In spite of their complications, ABO-incompatible liver transplantations are performed due to the shortage of suitable donors and the urgent need for organs. Despite developments in surgical techniques and improvements in antimicrobial prophylaxis strategies, infection is still an important complication and continues to be a major cause of death. In this study, ABO-compatible and ABO-incompatible liver transplant recipients were compared retrospectively in terms of infections and survival. Materials and Methods: Sixteen ABO-incompatible liver transplant recipients whose transplant surgeries were performed by the Liver Transplant Team between March 2002 and January 2011 were included in the study. ABO-compatible liver transplant recipients whose surgeries were undergone before and after the ABO-incompatible transplantation were selected as control group (total 32 patients). Patients’ postoperative one year data were obtained from hospital records in both groups. Results: In the first postoperative year after liver transplantation, 12 (75%) of the ABO-incompatible recipients and 21 (65.6%) of the ABO-compatible recipients experienced at least one infection attack (p=0.509). The infection attack rate was 175% in the ABO-incompatible group and 113% in the ABO-compatible group (p=0.262). Eight (50%) of the 16 ABO-incompatible recipients and nine (28.1%) of the 32 ABO-compatible recipients died within one year of transplantation (p=0.135). There were no statistically significant differences between the groups in terms of mortality or infection rates. Pseudomonas aeruginosa was the most common isolate in both ABO-compatible and incompatible recipients. Conclusion: The findings of the study showed that ABO-incompatible transplants were comparable to ABO-compatible transplants in terms of infection rates and survival. It should be kept in mind that ABO incompatible liver transplantation may be an option, especially in emergencies and in selected cases, despite differences in complications between centers and patient groups and concerns about greater complications in ABO-incompatible patients. However, further studies are needed on this topic.
Authors and Affiliations
Filiz SÜRÜCÜ BAYAR, Yaşar BAYINDIR, Burak IŞIK, Dinçer ÖZGÖR, Üner KAYABAŞ, Çiğdem KUZUCU, Sezai YILMAZ
Keywords
Related Articles
- EP ID EP689314
- DOI 10.4274/mjima.2018.14
- Views 142
- Downloads 0
Recreational Drugs and Antiretrovirals: Is It Worth the World or Trivial?
According to the World Health Organization, 1 out of 200 people in the world was living with Human immunodeficiency virus (HIV)/Acquired immune deficiency syndrome (AIDS) in 2015 and four new HIV infections occurred each...
Idiopathic CD4 Lymphocytopenia (HIV-Negative AIDS): Case Report and Literature Review
Idiopathic CD4 lymphocytopenia (ICL), also known as non-HIV AIDS, is a rare disease characterized by opportunistic infections, malignancies, and autoimmune diseases. Idiopathic CD4 lymphocytopenia is defined as CD4+ T-ly...
Evaluation of Infections in Hospitalised Pregnant Women
Introduction: Hormonal and immunological changes in pregnancy may lead to an increase in infectious diseases caused by some pathogens. In this study, we aimed to determine the types of infections and treatment approaches...
Cefoxitin: Interesting Perspectives on a Neglected Intravenous Beta-lactam
Cefoxitin is a beta-lactam antibiotic belonging to the cephamycins class, up to now only used in clinical practice for prophylaxis during surgery. Recently, its use has increased due to the spread of infections caused by...
Hijamah Associated Sepsis
No Abstract